ReviewScanning2019
Atomic Force Microscopy on Biological Materials Related to Pathological Conditions.
Review in Scanning, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 106 citations in OpenAlex.
- Atomic force microscopy-based nanomechanical signatures as cancer biomarkers in a nutshell.FEBS letters · 2026Review
- Mechanical Phenotyping of MG63s Following Vibrational Stimulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Current trends in exosomes as therapeutic drug delivery systems.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Article
- The Young's Modulus as a Mechanical Biomarker in AFM Experiments: A Tool for Cancer Diagnosis and Treatment Monitoring.Sensors (Basel, Switzerland) · 2025Review
- Mechanics and disease of heart cells/cardiomyocytes explored through atomic force microscopy: present and future.Biophysical reviews · 2025Review
- CellMAP: an open-source software tool to batch-process cell topography and stiffness maps collected with an atomic force microscope.BMC bioinformatics · 2025Article
- Article
- Article
- The matrix stiffness is increased in the eutopic endometrium of adenomyosis patients: a study based on atomic force microscopy and histochemistry.European journal of histochemistry : EJH · 2024Article
- High-Resolution Atomic Force Microscopy Investigation of Alginate Hydrogel Materials in Aqueous Media.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Unveiling exosomes: Cutting-edge isolation techniques and their therapeutic potential.Journal of cellular and molecular medicine · 2024Review
- Applying the Atomic Force Microscopy Technique in Medical Sciences-A Narrative Review.Biomedicines · 2024Review
- In Operando Imaging Electrostatic-Driven Disassembly and Reassembly of Collagen Nanostructures.ACS nano · 2024Article
- Short-Term l-arginine Treatment Mitigates Early Damage of Dermal Collagen Induced by Diabetes.Bioengineering (Basel, Switzerland) · 2024Article
- Evaluation of Surface Structure and Morphological Phenomena of Caucasian Virgin Hair with Atomic Force Microscopy.Medicina (Kaunas, Lithuania) · 2024Article
- Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy.Journal of the Royal Society, Interface · 2024Article
- Exploring the AβFrontiers in molecular biosciences · 2024Article
- A New Elementary Method for Determining the Tip Radius and Young's Modulus in AFM Spherical Indentations.Micromachines · 2023Article
- Multilevel Assessment of Stent-Induced Inflammation in the Adjacent Vascular Tissue.ACS biomaterials science & engineering · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atomic force microscopy (AFM) is an easy-to-use, powerful, high-resolution microscope that allows the user to image any surface and under any aqueous condition. AFM has been used in the investigation of the structural and mechanical properties of a wide range of biological matters including biomolecules, biomaterials, cells, and tissues. It provides the capacity to acquire high-resolution images of biosamples at the nanoscale and allows at readily carrying out mechanical characterization. The capacity of AFM to image and interact with surfaces, under physiologically relevant conditions, is of great importance for realistic and accurate medical and pharmaceutical applications. The aim of this paper is to review recent trends of the use of AFM on biological materials related to health and sickness. First, we present AFM components and its different imaging modes and we continue with combined imaging and coupled AFM systems. Then, we discuss the use of AFM to nanocharacterize collagen, the major fibrous protein of the human body, which has been correlated with many pathological conditions. In the next section, AFM nanolevel surface characterization as a tool to detect possible pathological conditions such as osteoarthritis and cancer is presented. Finally, we demonstrate the use of AFM for studying other pathological conditions, such as Alzheimer's disease and human immunodeficiency virus (HIV), through the investigation of amyloid fibrils and viruses, respectively. Consequently, AFM stands out as the ideal research instrument for exploring the detection of pathological conditions even at very early stages, making it very attractive in the area of bio- and nanomedicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.