Evidence map›Paper›PMID 31214249›Full record

ReviewFrontiers in genetics2019

Review of Causal Discovery Methods Based on Graphical Models.

Clark Glymour, Kun Zhang, Peter Spirtes

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Causal inference in the diagnosis and prognosis of ovarian cancer: current state and future directions.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Genetic analysis of imaging-derived phenotypes.Nature reviews. Genetics · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Bayesian Networks and Causal Discovery.Entropy (Basel, Switzerland) · 2026
    Article
  18. Causal Graphical Models and Their Applications.Entropy (Basel, Switzerland) · 2026
    Article
  19. Article
  20. Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clark GlymourDepartment of Philosophy, Carnegie Mellon University, Pittsburgh, PA, United States.
Kun ZhangDepartment of Philosophy, Carnegie Mellon University, Pittsburgh, PA, United States.
Peter SpirtesDepartment of Philosophy, Carnegie Mellon University, Pittsburgh, PA, United States.

Funding

TrainingU54HG008540 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BERG, JEREMY M · 2014 to 2018
$12.8M
Supplement Plan for EFFECTIVE CONNECTIVITY IN BRAIN NETWORKS: Detecting network disruption in Alzheimeir's using sub-second temporal resolutionR01EB022858 · NIBIB · RUTGERS THE STATE UNIV OF NJ NEWARK · PI HANSON, STEPHEN JOSÉ · 2016 to 2018
$1.6M
INTEGRATIVE GRAPHICAL MODELS FOR LARGE MULTI-MODAL BIOMEDICAL DATAR01LM012087 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, GLYMOUR, CLARK · 2015 to 2018
$1.3M
NHGRI NIH HHS U54 HG008540NIBIB NIH HHS R01 EB022858NLM NIH HHS R01 LM012087
6 · The paper itself

Abstract

A fundamental task in various disciplines of science, including biology, is to find underlying causal relations and make use of them. Causal relations can be seen if interventions are properly applied; however, in many cases they are difficult or even impossible to conduct. It is then necessary to discover causal relations by analyzing statistical properties of purely observational data, which is known as causal discovery or causal structure search. This paper aims to give a introduction to and a brief review of the computational methods for causal discovery that were developed in the past three decades, including constraint-based and score-based methods and those based on functional causal models, supplemented by some illustrations and applications.

Indexed as

causal discoveryconditional independencedirected graphical causal modelsnon-Gaussian distributionnon-linear modelsstatistical independencestructural equation models

Identifiers

PMID31214249
PMCPMC6558187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.