ReviewFrontiers in immunology2019
Paraneoplastic Pemphigus: Paraneoplastic Autoimmune Disease of the Skin and Mucosa.
Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV).Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Guideline
- Lichenoid variant of paraneoplastic pemphigus arising 1 week after thymoma resection.JAAD case reports · 2026Article
- Paraneoplastic Pemphigus/Paraneoplastic Autoimmune Multiorgan Syndrome Associated With Castleman Disease: Multidisciplinary Management of a Rare Life-Threatening Syndrome.Clinical case reports · 2026Article
- Paraneoplastic Pemphigus and Liver Biopsy Needle Track Dissemination in Hepatocellular Carcinoma: A Case Report.GE Portuguese journal of gastroenterology · 2026Article
- Autoantibody repertoire analysis in paraneoplastic pemphigus reveals novel targets linked to mucocutaneous blistering and bronchiolitis obliterans.Communications medicine · 2026Article
- Paraneoplastic Pemphigus Mimicking Stevens-Johnson Syndrome in a Patient with Multiple Myeloma: A Rare and Clinically Challenging Presentation.International journal of hematology-oncology and stem cell research · 2026Article
- Single-cell sequencing reveals dynamic immune features of paraneoplastic pemphigus in a patient with follicular lymphoma.Frontiers in immunology · 2026Article
- Paraneoplastic Pemphigus Associated With Renal Cell Carcinoma. Rare Case Report and Literature Review.Clinical medicine insights. Case reports · 2026Article
- Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab-Responsive Case With Diagnostic and Therapeutic Implications.Clinical case reports · 2025Article
- A case of erosive oral lichen planus in a child affected by β-Thalassemia after 5 years from bone marrow transplantation.BMC oral health · 2025Article
- Autoimmune bullous diseases: pathogenesis and clinical management.Molecular biomedicine · 2025Review
- Complete Resolution of Atypical Paraneoplastic Pemphigus Following Treatment With Dupilumab.Cureus · 2025Article
- Autoimmune pemphigus: difficulties in diagnosis and the molecular mechanisms underlying the disease.Frontiers in immunology · 2025Review
- A rare case report: retroperitoneal dedifferentiated liposarcoma associated with paraneoplastic pemphigus.Frontiers in surgery · 2025Article
- Case Report: Oral lichenoid mucositis in a patient with metastatic renal cell carcinoma undergoing treatment with pembrolizumab and axitinib.Frontiers in oncology · 2025Article
- Oral Paraneoplastic Pemphigus: A Scoping Review on Pathogenetic Mechanisms and Histo-Serological Profile.Antibodies (Basel, Switzerland) · 2024Article
- Lichenoid paraneoplastic pemphigus in a patient presenting with follicular lymphoma: a review of the literature.Archives of dermatological research · 2024Review
- [Autoimmune blistering dermatosis as a paraneoplastic syndrome secondary to testicular cancer].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Acute myeloid leukemia with paraneoplastic pemphigus successfully treated with a personalized antileukemic and immunosuppressive strategy.Annals of hematology · 2024Article
- Focus on pemphigus treatment publications: A bibliometric and visual analysis (1992-2022).Heliyon · 2024Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraneoplastic pemphigus (PNP) is a rare but life-threatening mucocutaneous disease mediated by paraneoplastic autoimmunity. Various neoplasms are associated with PNP. Intractable stomatitis and polymorphous cutaneous eruptions, including blisters and lichenoid dermatitis, are characteristic clinical features caused by humoral and cell-mediated autoimmune reactions. Autoreactive T cells and IgG autoantibodies against heterogeneous antigens, including plakin family proteins and desmosomal cadherins, contribute to the pathogenesis of PNP. Several mechanisms of autoimmunity may be at play in this disease on the type of neoplasm present. Diagnosis can be made based on clinical and histopathological features, the presence of anti-plakin autoantibodies, and underlying neoplasms. Immunosuppressive agents and biologics including rituximab have been used for the treatment of PNP; however, the prognosis is poor due to underlying malignancies, severe infections during immunosuppressive treatment, and bronchiolitis obliterans mediated by autoimmunity. In this review, we overview the characteristics of PNP and focus on the immunopathology and the potential pathomechanisms of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.