Evidence map›Paper›PMID 31214187›Full record

ArticleFrontiers in immunology2019

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.

David Ermert, Maisem Laabei, Antonin Weckel, Matthias Mörgelin, Martin Lundqvist, Lars Björck, Sanjay Ram, Sara Linse, Anna M Blom

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. Article
  3. Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

David ErmertDivision of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.
Maisem LaabeiDivision of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.
Antonin WeckelDivision of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.
Matthias MörgelinColzyx AB, Lund, Sweden.
Martin LundqvistDepartment of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, Lund, Sweden.
Lars BjörckDivision of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
Sanjay RamDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States.
Sara LinseDepartment of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, Lund, Sweden.
Anna M BlomDivision of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.
Lund University · SEUniversity of Massachusetts Chan Medical School · US

Funding

Novel immunotherapeutics against multidrug-resistant Neisseria gonorrhoeaR01AI132296 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY, RICE, PETER A. · 2017 to 2021
$5.5M
An immunotherapeutic to prevent gonorrheaR44AI147930 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI RAM, SANJAY, WYCOFF, KEITH · 2019 to 2021
$2.0M
Novel immunotherapeutics against multi-drug resistant Neisseria gonorrhoeaeR21AI111728 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY, SHAUGHNESSY, JUTAMAS · 2014 to 2015
$460k
NIAID NIH HHS R01 AI132296NIAID NIH HHS R21 AI111728
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunomodulationComplement C4b-Binding ProteinComplement Factor HDisease SusceptibilityHost-Pathogen InteractionsHumansImmunoglobulin GKineticsLigandsMultiprotein ComplexesProtein BindingProtein MultimerizationStreptococcal InfectionsStreptococcus pyogenesCFH protein, humanComplement C4b-Binding ProteinComplement Factor HImmunoglobulin GLigandsMultiprotein Complexesimmunoglobulin G (IgG)infectious diseaseprotein complexprotein-protein interactionprotein stabilitystoichiometryStreptococcus pyogenes (S. pyogenes)the complement system

Identifiers

PMID31214187
PMCPMC6557989
OpenAlexW2946822583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.