ArticleFrontiers in immunology2019
Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Distinct inflammatory profiles across migraine states: a systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- Cytokines in primary headache disorders: a systematic review and meta-analysis.The journal of headache and pain · 2023Pooled it
- Vestibular migraine treatment: a comprehensive practical review.Brain : a journal of neurology · 2022Pooled it
- Systemic immune-inflammation index and prognostic nutritional index in vestibular migraine and Meniere's disease: a retrospective comparison with healthy controls.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Integrated Identification of NAD⁺ Metabolism-Associated Candidate Genes.Molecular neurobiology · 2026Article
- Epidemiological and clinical differences in Meniere disease across European and East Asian populations.The Journal of international medical research · 2026Review
- Modern Perspectives on the Mechanisms and Non-Genetic Factors in Ménière's Disease-A Narrative Review.Biomedicines · 2026Review
- The Impact of Genetic Factors in Ménière's Disease.International journal of molecular sciences · 2026Review
- Peripheral Immune and Metabolic Dysregulation in Migraine, Ménière's Disease, and Vestibular Migraine: A Single-Cell Atlas Study.Human mutation · 2026Article
- Vestibular migraine vs. migraine only: integrated transcriptome-clinical profiling reveals shared inflammation and divergent metabolic pathways for targeted therapy.European journal of medical research · 2025Article
- CXCL10 Involvement in Vestibular Migraine via the PI3K/AKT Signaling Pathway.CNS neuroscience & therapeutics · 2025Article
- Vestibular Migraine Revisited: A Narrative Review of Diagnostic Challenges and Treatment Strategies.The journal of international advanced otology · 2025Review
- Article
- Insights into Vestibular Migraine: Diagnostic Challenges, Differential Spectrum and Therapeutic Horizons.Journal of clinical medicine · 2025Review
- Immunological mechanisms in Meniere's disease.Frontiers in immunology · 2025Review
- Review
- Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders.Journal of otology · 2024Article
- Altered immunity in migraine: a comprehensive scoping review.The journal of headache and pain · 2024Article
- Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease.Genes and immunity · 2024Article
- Histaminergic System and Vestibular Function in Normal and Pathological Conditions.Current neuropharmacology · 2024Review
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vestibular Migraine (VM) and Meniere's Disease (MD) are episodic vestibular syndromes defined by a set of associated symptoms such as tinnitus, hearing loss or migraine features during the attacks. Both conditions may show symptom overlap and there is no biological marker to distinguish them. Two subgroups of MD patients have been reported, according to their IL-1β profile. Therefore, considering the clinical similarity between VM and MD, we aimed to investigate the cytokine profile of MD and VM as a means to distinguish these patients. We have also carried out gene expression microarrays and measured the levels of 14 cytokines and 11 chemokines in 129 MD patients, 82 VM patients, and 66 healthy controls. Gene expression profile in peripheral blood mononuclear cells (PBMC) showed significant differences in MD patients with high and low basal levels of IL- 1β and VM patients. MD patients with high basal levels of IL- 1β (MDH) had overall higher levels of cytokines/chemokines when compared to the other subsets. CCL4 levels were significantly different between MDH, MD with low basal levels of IL- 1β (MDL), VM and controls. Logistic regression identified IL- 1β, CCL3, CCL22, and CXCL1 levels as capable of differentiating VM patients from MD patients (area under the curve = 0.995), suggesting a high diagnostic value in patients with symptoms overlap.
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