ArticleFrontiers in physiology2019
Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- CD8Immunity & ageing : I & A · 2026Article
- Eccentric treadmill training and skeletal muscle immunometabolic responses in HFD-induced insulin resistance.Frontiers in immunology · 2026Article
- Modulating CD8⁺ T cell immunity through exercise: mechanistic insights and implications for precision immunotherapy.Theranostics · 2026Review
- Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy.International journal of biological sciences · 2025Review
- T Cell Aging: An Important Target for Perioperative Immunomodulation.Clinical interventions in aging · 2025Review
- Role of Enhancing Aerobic Capacity in Countering COVID-19-induced Liver Injury in Elderlies.Endocrine, metabolic & immune disorders drug targets · 2024Review
- 12-week combined strength and endurance exercise attenuates CD8Immunity & ageing : I & A · 2023Article
- The effects of exercise training for eight weeks on immune cell characteristics among breast cancer survivors.Frontiers in sports and active living · 2023Article
- Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers: Appraising Exercise-Induced Immuno-Modulation As An Integral Mechanism.Frontiers in oncology · 2022Review
- Immunological mechanisms of exercise therapy in dyslipidemia.Frontiers in physiology · 2022Review
- Neutralizing a Springboard for Inflammation: Physical Activity to Control the Immune Network.Healthcare (Basel, Switzerland) · 2021Article
- The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society.Nutrients · 2021Review
- DNA Methylation Patterns in CD8Frontiers in cell and developmental biology · 2021Article
- Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects.Frontiers in physiology · 2021Article
- Physical Activity and Diet Shape the Immune System during Aging.Nutrients · 2020Review
- Thromboinflammation and COVID-19: The Role of Exercise in the Prevention and Treatment.Frontiers in cardiovascular medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.