Evidence map›Paper›PMID 31213673›Full record

ReviewNature reviews. Immunology2019

Photoimmunology: how ultraviolet radiation affects the immune system.

Jamie J Bernard, Richard L Gallo, Jean Krutmann

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 2 pooled it
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 2 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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  16. [Chronic skin damage from UV radiation].Dermatologie (Heidelberg, Germany) · 2026
    Review
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jamie J BernardDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA. jbernard@msu.edu.ORCID http://orcid.org/0000-0002-3800-2576
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1401-7861
Jean KrutmannIUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Leibniz Institute of Environmental Medicine · DEMichigan State University · USUniversity of California San Diego · US

Funding

Cathelicidins in Skin ImmunityR01AI052453 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GALLO, RICHARD L, NIZET, VICTOR · 2002 to 2017
$5.3M
Skin Defense by Dermal AdipocytesR01AR069653 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI052453NIAMS NIH HHS R01 AR069653
6 · The paper itself

Abstract

Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn and is a potent immunomodulator, yet longer-wavelength, lower-energy UVA radiation also has effects on mammalian immunity. This Review discusses current knowledge regarding the mechanisms by which UV radiation can modify innate and adaptive immune responses and how this immunomodulatory capacity can be both beneficial in the case of inflammatory and autoimmune diseases, and detrimental in the case of skin cancer and the response to several infectious agents.

Indexed as

Ultraviolet RaysAdaptive ImmunityAntimicrobial Cationic PeptidesDNA DamageHumansImmune SystemImmunity, InnateReceptors, Aryl HydrocarbonReceptors, Pattern RecognitionUrocanic AcidAntimicrobial Cationic PeptidesReceptors, Aryl HydrocarbonReceptors, Pattern RecognitionUrocanic Acid

Identifiers

PMID31213673
OpenAlexW2952827414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.