ArticleScientific reports2019
Water dynamics in MCF-7 breast cancer cells: a neutron scattering descriptive study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Inelastic Neutron Scattering: Prospects for Measuring Atomic Vibrations of Nucleic Acids.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Sub-Nanosecond Dynamics of Pathologically Relevant Bio-Macromolecules Observed by Incoherent Neutron Scattering.Life (Basel, Switzerland) · 2022Review
- Exploring the Limits of Biological Complexity Amenable to Studies by Incoherent Neutron Spectroscopy.Life (Basel, Switzerland) · 2022Review
- Water Dynamics in Cancer Cells: Lessons from Quasielastic Neutron Scattering.Medicina (Kaunas, Lithuania) · 2022Review
- Increase in the Intracellular Bulk Water Content in the Early Phase of Cell Death of Keratinocytes, Corneoptosis, as Revealed by 65 GHz Near-Field CMOS Dielectric Sensor.Molecules (Basel, Switzerland) · 2022Article
- Optical Fiber, Nanomaterial, and THz-Metasurface-Mediated Nano-Biosensors: A Review.Biosensors · 2022Review
- Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy.ACS omega · 2020Article
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Authors and funding
8 authors.
Funding
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Abstract
Water mobility in cancer cells could be a powerful parameter to predict the progression or remission of tumors. In the present descriptive work, new insight into this concept was achieved by combining neutron scattering and thermal analyses. The results provide the first step to untangle the role played by water dynamics in breast cancer cells (MCF-7) after treatment with a chemotherapy drug. By thermal analyses, the cells were probed as micrometric reservoirs of bulk-like and confined water populations. Under this perspective we showed that the drug clearly alters the properties of the confined water. We have independently validated this idea by accessing the cellular water dynamics using inelastic neutron scattering. Finally, analysis of the quasi-elastic neutron scattering data allows us to hypothesize that, in this particular cell line, diffusion increases in the intracellular water in response to the action of the drug on the nanosecond timescale.
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