ArticleScientific reports2019
Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Meniscal repair: The current state and recent advances in augmentation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Pooled it
- Pneumatospinning and Electrospinning Scaffolds for Meniscus Regeneration Using Human Embryonic-Derived Mesenchymal Stem Cells.Bioengineering (Basel, Switzerland) · 2026Article
- Core-Shell Codelivery Nanocarrier Synergistically Regulates Cartilaginous Immune Microenvironment for Total Meniscus Replacement.ACS nano · 2025Article
- Advances in repair of non-discoid meniscus injuries in children: a narrative review.Frontiers in pediatrics · 2025Review
- Collagen-Based Scaffolds for Meniscal Repair and Regeneration.Journal of tissue engineering and regenerative medicine · 2025Review
- Cyclic compressive loading induces a mature meniscal cell phenotype in mesenchymal stem cells with an atelocollagen-based scaffold.Frontiers in bioengineering and biotechnology · 2024Article
- Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair.Frontiers in bioengineering and biotechnology · 2024Article
- Bioengineered human tissue regeneration and repair using endogenous stem cells.Cell reports. Medicine · 2023Article
- Allografts for partial meniscus repair: anFrontiers in bioengineering and biotechnology · 2023Article
- Meniscus repair: up-to-date advances in stem cell-based therapy.Stem cell research & therapy · 2022Review
- Natural biopolymer scaffold for meniscus tissue engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Demineralized Cortical Bone Matrix Augmented With Peripheral Blood-Derived Mesenchymal Stem Cells for Rabbit Medial Meniscal Reconstruction.Frontiers in bioengineering and biotechnology · 2022Article
- Applications and prospects of different functional hydrogels in meniscus repair.Frontiers in bioengineering and biotechnology · 2022Review
- A review of strategies for development of tissue engineered meniscal implants.Biomaterials and biosystems · 2021Review
- Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Development of a decellularized meniscus matrix-based nanofibrous scaffold for meniscus tissue engineering.Acta biomaterialia · 2021Article
- Segmental Meniscus Allograft Transplantation.Arthroscopy techniques · 2021Article
- The Role of Collagen-Based Biomaterials in Chronic Wound Healing and Sports Medicine Applications.Bioengineering (Basel, Switzerland) · 2021Review
- Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.Frontiers in cell and developmental biology · 2021Review
- Injectable ECM hydrogel for delivery of BMSCs enabled full-thickness meniscus repair in an orthotopic rat model.Bioactive materials · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Meniscal tears have a poor healing capacity, and damage to the meniscus is associated with significant pain, disability, and progressive degenerative changes in the knee joint that lead to osteoarthritis. Therefore, strategies to promote meniscus repair and improve meniscus function are needed. The objective of this study was to generate porcine meniscus-derived matrix (MDM) scaffolds and test their effectiveness in promoting meniscus repair via migration of endogenous meniscus cells from the surrounding meniscus or exogenously seeded human bone marrow-derived mesenchymal stem cells (MSCs). Both endogenous meniscal cells and MSCs infiltrated the MDM scaffolds. In the absence of exogenous cells, the 8% MDM scaffolds promoted the integrative repair of an in vitro meniscal defect. Dehydrothermal crosslinking and concentration of the MDM influenced the biochemical content and shear strength of repair, demonstrating that the MDM can be tailored to promote tissue repair. These findings indicate that native meniscus cells can enhance meniscus healing if a scaffold is provided that promotes cellular infiltration and tissue growth. The high affinity of cells for the MDM and the ability to remodel the scaffold reveals the potential of MDM to integrate with native meniscal tissue to promote long-term repair without necessarily requiring exogenous cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.