Evidence map›Paper›PMID 31213603›Full record

ArticleNature communications2019

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function.

Chiara Montemurro, Hiroshi Nomoto, Lina Pei, Vishal S Parekh, Kenny E Vongbunyong, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E Butler, Rohan Subramaniam, Eleni Ritou and 4 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 83 citations in OpenAlex.

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  12. A Fresh Look at Islet Isolation from Rabbit Pancreases.International journal of molecular sciences · 2024
    Article
  13. Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy.Signal transduction and targeted therapy · 2024 · on this map
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Chiara MontemurroLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.ORCID http://orcid.org/0000-0002-7070-2724
Hiroshi NomotoLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.ORCID http://orcid.org/0000-0003-0713-221X
Lina PeiLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Vishal S ParekhDepartment of Pharmacology and Brehm Diabetes Research Center, University of Michigan, Ann Arbor, MI, 48105, USA.
Kenny E VongbunyongLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Suryakiran VadrevuDepartment of Pharmacology and Brehm Diabetes Research Center, University of Michigan, Ann Arbor, MI, 48105, USA.
Tatyana GurloLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Alexandra E ButlerLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Rohan SubramaniamLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Eleni RitouDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Orian S ShirihaiDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Leslie S SatinDepartment of Pharmacology and Brehm Diabetes Research Center, University of Michigan, Ann Arbor, MI, 48105, USA.
Peter C ButlerLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Slavica TudzarovaLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA. STudzarova@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-9617-3779
University of California, Los Angeles · USUniversity of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023
$9.1M
Role of IAPP in Islet Dysfunction in DiabetesR01DK059579 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUTLER, PETER CAWOOD · 2001 to 2019
$7.5M
Capacity and Mechanisms of Beta Cell Regeneration in HumansR01DK077967 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTLER, PETER CAWOOD · 2008 to 2016
$2.5M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK046409NIDDK NIH HHS R01 DK059579NIDDK NIH HHS R01 DK077967NIDDK NIH HHS U24 DK098085
6 · The paper itself

Abstract

The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers implicated in misfolded protein stress. Here, we establish that hIAPP misfolded protein stress activates HIF1α/PFKFB3 signaling, this increases glycolysis disengaged from oxidative phosphorylation with mitochondrial fragmentation and perinuclear clustering, considered a protective posture against increased cytosolic Ca

Indexed as

AdultAnimalsAnimals, Genetically ModifiedApoptosisCell Line, TumorDiabetes Mellitus, Type 2Disease Models, AnimalEndoplasmic Reticulum StressGlycolysisHumansHypoxia-Inducible Factor 1, alpha SubunitInsulin-Secreting CellsIslet Amyloid PolypeptideMaleMiddle AgedMitophagyHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIslet Amyloid PolypeptidePFKFB3 protein, humanPhosphofructokinase-2Protein Aggregates

Identifiers

PMID31213603
PMCPMC6581914
OpenAlexW2951374313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.