Evidence map›Paper›PMID 31213573›Full record

ArticleBioscience reports2019

Allicin alleviates lead-induced hematopoietic stem cell aging by up-regulating PKM2.

Shi-Zhong Cai, Li-Na Zhao, Jun Liu, Yi-Ting Ji, Xiao-Yan Shi, Zhou-Rui Ma, Xiao-Hua Lv, Ke Chen, Yan Chen

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Immunometabolic control of hematopoiesis.Molecular aspects of medicine · 2021
    Review
  7. Antioxidative properties ofToxicology reports · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shi-Zhong CaiDepartment of Child and Adolescent Healthcare, The Children's Hospital of Soochow University, Suzhou 215021, Jiangsu, China.
Li-Na ZhaoCenter for Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Jun LiuJiangsu Institute of Hematology, The First Affiliated Hospital and Collaborative Innovation Center of Hematology, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, Jiangsu, China.
Yi-Ting JiDepartment of Child and Adolescent Healthcare, The Children's Hospital of Soochow University, Suzhou 215021, Jiangsu, China.
Xiao-Yan ShiDepartment of Child and Adolescent Healthcare, The Children's Hospital of Soochow University, Suzhou 215021, Jiangsu, China.
Zhou-Rui MaDepartment of Cineplastic Surgery, The Children's Hospital of Soochow University, Suzhou 215021, Jiangsu, China.
Xiao-Hua LvDepartment of Pharmacology, Guangdong Medical University, Zhanjiang 524023, Guangdong, China.
Ke ChenDepartment of Spine Surgery, Shenzhen People's Hospital, Jinan University Second College of Medicine, Shenzhen 518020, Guangdong, China chenyan0823@189.cn Xiao.han79@163.com.
Yan ChenDepartment of Child and Adolescent Healthcare, The Children's Hospital of Soochow University, Suzhou 215021, Jiangsu, China chenyan0823@189.cn Xiao.han79@163.com.ORCID 0000-0002-4139-3774
Soochow University · CNGuangdong Medical College · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) aging is associated with hematopoietic dysfunction and diseases. Our previous study showed that lead exposure induced a functional decline in HSCs. Allicin, a chemical extracted from the garlic (

Indexed as

AgingAnimalsAntioxidantsCell ProliferationDisulfidesDNA DamageGene Expression Regulation, DevelopmentalHematopoietic Stem CellsHumansMiceProtein IsoformsPyruvate KinaseSulfinic AcidsallicinAntioxidantsDisulfidesPkm protein, mouseProtein IsoformsPyruvate KinaseSulfinic AcidsAgingAllicinHematopoietic stem cellLeadPKM2

Identifiers

PMID31213573
PMCPMC6609558
OpenAlexW2951501458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.