Evidence map›Paper›PMID 31213557›Full record

ArticlemBio2019

Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli.

Anna M Köhler, Rebekka Harting, Annika E Langeneckert, Oliver Valerius, Jennifer Gerke, Cindy Meister, Anja Strohdiek, Gerhard H Braus

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Fungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylase.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Review
  7. Experimental evidence for the functional importance and adaptive advantage of A-to-I RNA editing in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anna M KöhlerDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Rebekka HartingDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Annika E LangeneckertDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Oliver ValeriusDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Jennifer GerkeDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Cindy MeisterDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Anja StrohdiekDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.
Gerhard H BrausDepartment of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany gbraus@gwdg.de.ORCID 0000-0002-3117-5626
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

E3 cullin-RING ubiquitin ligase (CRL) complexes recognize specific substrates and are activated by covalent modification with ubiquitin-like Nedd8. Deneddylation inactivates CRLs and allows Cand1/A to bind and exchange substrate recognition subunits. Human as well as most fungi possess a single gene for the receptor exchange factor Cand1, which is split and rearranged in aspergilli into two genes for separate proteins.

Indexed as

Aspergillus nidulansCullin ProteinsFungal ProteinsMultiprotein ComplexesUbiquitinUbiquitin-Protein LigasesCul3 protein, mouseCullin ProteinsFungal ProteinsMultiprotein ComplexesUbiquitinUbiquitin-Protein Ligasesasexual developmentAspergillus fumigatusAspergillus nidulansCand1COP9 signalosomeCullin-RING ubiquitin ligaseNedd8protein complexprotein degradationsecondary metabolismsexual developmentspore germination

Identifiers

PMID31213557
PMCPMC6581859
OpenAlexW2950707734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.