Evidence map›Paper›PMID 31213556›Full record

ArticlemBio2019

Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways.

Melinda A Engevik, Berkley Luk, Alexandra L Chang-Graham, Anne Hall, Beatrice Herrmann, Wenly Ruan, Bradley T Endres, Zhongcheng Shi, Kevin W Garey, Joseph M Hyser and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 6 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 6 syntheses or guidelines pooled it, 269 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in microbiology · 2025
    Pooled it
  3. Pooled it
  4. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Gut microbiota modulation of systemic immunity and cancer immunotherapy: mechanisms, evidence, and therapeutic implications.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  12. Article
  13. Galacto-Oligosaccharides Reshape MucinJournal of agricultural and food chemistry · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in cellular and infection microbiology · 2026
    Article
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Melinda A EngevikDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA melinda.engevik@bcm.edu.ORCID 0000-0002-9742-9932
Berkley LukDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-5996-876X
Alexandra L Chang-GrahamDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Anne HallDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-6814-6514
Beatrice HerrmannDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Wenly RuanDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Bradley T EndresDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
Zhongcheng ShiDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Kevin W GareyDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0003-2063-7503
Joseph M HyserDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
James VersalovicDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Baylor College of Medicine · USUniversity of Houston · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9M
Training Supplement in Enteric Virus Exploitation of Calcium SignalingR01DK115507 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Joseph M. Hyser · 2018 to 2026
$5.0M
Gut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8M
Regulation of Enteric Virus Secretory DiarrheaR03DK110270 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HYSER, JOSEPH M. · 2017 to 2018
$159k
NCI NIH HHS U01 CA170930NIAID NIH HHS U01 AI124290NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK115507NIDDK NIH HHS R03 DK110270
6 · The paper itself

Abstract

Much remains unknown about how the intestinal microbiome interfaces with the protective intestinal mucus layer.

Indexed as

AutophagyCalcium SignalingHost Microbial InteractionsAnimalsBifidobacteriumFemaleGastrointestinal MicrobiomeGerm-Free LifeGoblet CellsIntestinal MucosaKruppel-Like Factor 4MaleMiceMucin-2MucinsPolysaccharidesKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Muc2 protein, mouseMucin-2MucinsPolysaccharidesacetatebifidobacteriaepitheliumGABAglycansgoblet cellsgut microbesintestineMuc2mucinsprobiotics

Identifiers

PMID31213556
PMCPMC6581858
OpenAlexW2951351243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.