ArticleProceedings of the National Academy of Sciences of the United States of America2019
The network organization of rat intrathalamic macroconnections and a comparison with other forebrain divisions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Intrinsic neuronal network organization of a mammalian peripheral nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Electrophysiological connections linking medial pulvinar, anterior nuclei of the thalamus and the hippocampus.Brain : a journal of neurology · 2025Article
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- Topographic organization of bidirectional connections between the cingulate region (infralimbic area and anterior cingulate area, dorsal part) and the interbrain (diencephalon) of the adult male rat.bioRxiv : the preprint server for biology · 2024Article
- Neural network architecture of a mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Network architecture of intrinsic connectivity in a mammalian spinal cord (the central nervous system's caudal sector).Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sound suppresses earliest visual cortical processing after sight recovery in congenitally blind humans.Communications biology · 2024Article
- Intrinsic circuitry of the rhombicbrain (central nervous system's intermediate sector) in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structure-function subsystem model and computational lesions of the central nervous system's rostral sector (forebrain and midbrain).Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Look-up and look-down neurons in the mouse visual thalamus during freely moving exploration.Current biology : CB · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Article
- Subsystem macroarchitecture of the intrinsic midbrain neural network and its tectal and tegmental subnetworks.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Analysis of the Neuron Dynamics in Thalamic Reticular Nucleus by a Reduced Model.Frontiers in computational neuroscience · 2021Article
- Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mapping the community structure of the rat cerebral cortex with weighted stochastic block modeling.Brain structure & function · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thalamus is 1 of 4 major divisions of the forebrain and is usually subdivided into epithalamus, dorsal thalamus, and ventral thalamus. The 39 gray matter regions comprising the large dorsal thalamus project topographically to the cerebral cortex, whereas the much smaller epithalamus (2 regions) and ventral thalamus (5 regions) characteristically project subcortically. Before analyzing extrinsic inputs and outputs of the thalamus, here, the intrinsic connections among all 46 gray matter regions of the rat thalamus on each side of the brain were expertly collated and subjected to network analysis. Experimental axonal pathway-tracing evidence was found in the neuroanatomical literature for the presence or absence of 99% of 2,070 possible ipsilateral connections and 97% of 2,116 possible contralateral connections; the connection density of ipsilateral connections was 17%, and that of contralateral connections 5%. One hub, the reticular thalamic nucleus (of the ventral thalamus), was found in this network, whereas no high-degree rich club or clear small-world features were detected. The reticular thalamic nucleus was found to be primarily responsible for conferring the property of complete connectedness to the intrathalamic network in the sense that there is, at least, one path of finite length between any 2 regions or nodes in the network. Direct comparison with previous investigations using the same methodology shows that each division of the forebrain (cerebral cortex, cerebral nuclei, thalamus, hypothalamus) has distinct intrinsic network topological organization. A future goal is to analyze the network organization of connections within and among these 4 divisions of the forebrain.
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