ArticleProceedings of the National Academy of Sciences of the United States of America2019
PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
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126citing papers in PubMed, 1 pooled it
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Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it, 216 citations in OpenAlex.
- Association between glycolysis markers and prognosis of liver cancer: a systematic review and meta-analysis.World journal of surgical oncology · 2023Pooled it
- Integrative multi-omics and machine learning reveal glycolysis-related biomarkers driving vascular remodeling in pulmonary arterial hypertension.Molecular and cellular biochemistry · 2026Article
- YWHAZ-mediated metabolic reprogramming via HIF1A/LDHA signaling promotes pulmonary arterial remodelling.Cell death discovery · 2026Article
- Exploring the therapeutic potential of GLP-1 receptor agonists in pulmonary arterial hypertension.ERJ open research · 2026Review
- The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.Cellular and molecular life sciences : CMLS · 2026Article
- Beyond a metabolite: lactate and lactylation in lung diseases.Respiratory research · 2026Review
- Glucose Metabolic Enzyme PFKFB3 in Cardiopulmonary Vascular Health and Disease.Circulation research · 2026Review
- Nicotinamide phosphoribosyltransferase activates the mitochondrial unfolded protein response to promote pulmonary arterial endothelial cell proliferation.bioRxiv : the preprint server for biology · 2026Article
- PFKFB3 Mediated Glycolytic Reprogramming Drives Vascular Endothelial Injury Under Chronic Intermittent Hypoxia.International journal of biological sciences · 2026Article
- Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis.Cell death discovery · 2025Review
- Adenosine Triggers an ADK-Dependent Intracellular Signaling Pathway Interacts PFKFB3-Mediated Glycolytic Metabolism to Promote Newly Formed Myofibers Development.International journal of molecular sciences · 2025Article
- Endothelial cell metabolism in cardiovascular physiology and disease.Nature reviews. Cardiology · 2025Review
- The P4HA1/HIF1α feedback loop modulates endothelial dysfunction in pulmonary hypertension.Respiratory research · 2025Article
- Reprogrammed glucose metabolism in vascular smooth muscle cells and its implications for vascular diseases.Pharmacological research · 2025Review
- Rewriting the vascular script: epigenetic modifiers as scribes of metabolic reprogramming in pulmonary hypertension.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Deciphering the Anti-Cancer Efficacy of the Combination of Small-Molecule Inhibitor KAN0438757 and Curcumin in Lung Cancer Cell Lines.Current issues in molecular biology · 2025Article
- Lactylation in Cardiovascular Diseases: Current Progress and Perspectives.Journal of the American Heart Association · 2025Review
- Role of COUP‑TFII in cardiovascular diseases and colorectal cancer: Insights into the molecular mechanisms and clinical relevance (Review).Molecular medicine reports · 2025Review
- Lactate and Lactylation in Respiratory Diseases: from Molecular Mechanisms to Targeted Strategies.Lung · 2025Review
- Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges.Journal of advanced research · 2025Review
66 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 4 institutions in 2 countries.
Yapeng CaoDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Xiaoyu ZhangDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Lina WangDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Qiuhua YangDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Qian MaDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Jiean XuDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Jingjing WangDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Laszlo KovacsDepartment of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Ramon J AyonDivision of Translational and Regenerative Medicine, Department of Medicine, University of Arizona, Tucson, AZ 85721-0202.
Zhiping LiuDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Min ZhangDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Yaqi ZhouDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Xianqiu ZengDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Yiming XuVascular Biology Center, Augusta University, Augusta, GA 30912.
Yong WangVascular Biology Center, Augusta University, Augusta, GA 30912.
David J FultonVascular Biology Center, Augusta University, Augusta, GA 30912.
Neal L WeintraubVascular Biology Center, Augusta University, Augusta, GA 30912.ORCID 0000-0002-5138-3705
Rudolf LucasVascular Biology Center, Augusta University, Augusta, GA 30912.
Zheng DongDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Jason X-J YuanDivision of Translational and Regenerative Medicine, Department of Medicine, University of Arizona, Tucson, AZ 85721-0202.
Jennifer C SullivanDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Louise MeadowsDepartment of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Scott A BarmanDepartment of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912.
Chaodong WuDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX 77840.
Junmin QuanDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China.
Mei HongDrug Discovery Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 518055 Shenzhen, China; meihong.sz@pku.edu.cn ysu@augusta.edu yhuo@augusta.edu.
Yunchao SuDepartment of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912; meihong.sz@pku.edu.cn ysu@augusta.edu yhuo@augusta.edu.
Yuqing HuoVascular Biology Center, Augusta University, Augusta, GA 30912; meihong.sz@pku.edu.cn ysu@augusta.edu yhuo@augusta.edu.ORCID 0000-0002-0305-4122
Peking University · CNAugusta University · USUniversity of Arizona · USTexas A&M University · US
Funding
Galectin-3: A mediator of vascular remodeling in pulmonary arterial hypertensionR01HL125926 · NHLBI · AUGUSTA UNIVERSITY · PI BARMAN, SCOTT A, FULTON, DAVID J · 2016 to 2025
$4.9MPFKFB3 in vascular remodelingR01HL134934 · NHLBI · AUGUSTA UNIVERSITY · PI HUO, YUQING, SU, YUNCHAO · 2017 to 2020
$2.3MMechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysmR01HL142097 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2018 to 2021
$2.1MENaC-α mediates lung fluid clearance and capillary barrier function in pneumoniaR01HL138410 · NHLBI · AUGUSTA UNIVERSITY · PI LUCAS, RUDOLF · 2018 to 2021
$2.0MEpigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8MProtective role of adenosine 2A receptor in NAFLDR01DK095862 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI WU, CHAODONG · 2013 to 2017
$1.6MAirway and Lung Vascular Remodeling in COPDI01BX002035 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI SU, YUNCHAO · 2015 to 2018
–BLRD VA I01 BX002035NHLBI NIH HHS R01 HL125926NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134934NHLBI NIH HHS R01 HL138410NHLBI NIH HHS R01 HL142097NIDDK NIH HHS R01 DK095862
Abstract
Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether glycolytic regulator 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3)-mediated endothelial glycolysis plays a critical role in the development of PH. Heterozygous global deficiency of
Indexed as
GlycolysisAnimalsDisease Models, AnimalEndotheliumGene Knockdown TechniquesHumansHypertension, PulmonaryHypoxiaLungMaleMiceMice, Inbred C57BLPhosphofructokinase-2RatsRats, Sprague-DawleyPFKFB3 protein, mousePhosphofructokinase-2endothelial cellsglycolysispulmonary hypertension
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.