Evidence map›Paper›PMID 31213481›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Discriminative Stimulus and Low Abuse Liability Effects of Novel Endomorphin Analogs Suggest a Potential Treatment Indication for Opioid Use Disorder.

Mark R Nilges, Morgan Laurent, Chloe Cable, Louis Arens, James Vafiades, James E Zadina

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mark R NilgesSoutheast Louisiana Veterans Health Care System (J.E.Z.), Departments of Medicine (J.E.Z.), Neuroscience (M.R.N., M.L., C.C., L.A., J.V., J.E.Z.), and Pharmacology (J.E.Z.), Tulane University School of Medicine, New Orleans, Louisiana.
Morgan LaurentSoutheast Louisiana Veterans Health Care System (J.E.Z.), Departments of Medicine (J.E.Z.), Neuroscience (M.R.N., M.L., C.C., L.A., J.V., J.E.Z.), and Pharmacology (J.E.Z.), Tulane University School of Medicine, New Orleans, Louisiana.
Chloe CableSoutheast Louisiana Veterans Health Care System (J.E.Z.), Departments of Medicine (J.E.Z.), Neuroscience (M.R.N., M.L., C.C., L.A., J.V., J.E.Z.), and Pharmacology (J.E.Z.), Tulane University School of Medicine, New Orleans, Louisiana.
Louis ArensSoutheast Louisiana Veterans Health Care System (J.E.Z.), Departments of Medicine (J.E.Z.), Neuroscience (M.R.N., M.L., C.C., L.A., J.V., J.E.Z.), and Pharmacology (J.E.Z.), Tulane University School of Medicine, New Orleans, Louisiana.
James VafiadesSoutheast Louisiana Veterans Health Care System (J.E.Z.), Departments of Medicine (J.E.Z.), Neuroscience (M.R.N., M.L., C.C., L.A., J.V., J.E.Z.), and Pharmacology (J.E.Z.), Tulane University School of Medicine, New Orleans, Louisiana.
James E ZadinaSoutheast Louisiana Veterans Health Care System (J.E.Z.), Departments of Medicine (J.E.Z.), Neuroscience (M.R.N., M.L., C.C., L.A., J.V., J.E.Z.), and Pharmacology (J.E.Z.), Tulane University School of Medicine, New Orleans, Louisiana jzadina@tulane.edu.
Southeast Louisiana Veterans Health Care System · USTulane University · US

Funding

A Novel Analgesic with Reduced Side Effects and Abuse Liability Relative to Morphine, With Potential for Opioid Dependence TherapyI01BX003776 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI ZADINA, JAMES E · 2018 to 2022
–
BLRD VA I01 BX003776
6 · The paper itself

Abstract

Opioid dependence can be difficult to manage using existing pharmacotherapies. A long-acting opioid with low abuse liability that substitutes for a shorter-acting opioid may improve treatment of opioid use disorders (OUDs). We recently characterized an endomorphin (EM) analog (ZH853) that produced a longer duration of antinociception compared with morphine, but did not produce self-administration or several other adverse effects preclinically. Here, we further characterized ZH853 in tests of antinociception, abuse liability, and drug discrimination. A conditioned place preference (CPP) procedure, that included a locomotor activity assessment, was used to test abuse liability in rats. Subsequently, dopamine (DA) cell-somas located in the ventral tegmental area (VTA) from these rats were assessed by size using immunohistochemistry and Stereo Investigator software. A hot-plate antinociception test in male and female mice confirmed central penetration. Morphine-substitution effects of several EM analogs (ZH850, ZH831, and ZH853) were tested in a drug discrimination (DD) procedure in rats. Morphine produced dose-dependent CPP and locomotor sensitization and reduced the size of DA cell somas in VTA, whereas ZH853 did not produce any of these effects relative to control. The antinociceptive effects of ZH853 were

Indexed as

AnimalsBehavior, AnimalDopamineDose-Response Relationship, DrugLocomotionMaleOligopeptidesOpioid-Related DisordersRatsRats, Sprague-DawleyVentral Tegmental AreaDopamineOligopeptides

Identifiers

PMID31213481
PMCPMC6695504
OpenAlexW2950129181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.