ArticleProceedings. Biological sciences2019
The effects of the neonicotinoid imidacloprid on gene expression and DNA methylation in the buff-tailed bumblebee Bombus terrestris.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Species-specific brain transcriptomic responses to clothianidin and sulfoxaflor in pollinators.iScience · 2026Article
- How Environmental and Ecological Stressors Reprogram Honey Bee Chemistry Through the Microbiome-Metabolome Axis.Insects · 2026Review
- Pesticide and Pathogen Exposure Causes Idiosyncratic Gene Expression Responses Across Four Diverse North American Bumble Bee Species.Molecular ecology · 2025Article
- A Genome-Wide Analysis of Structure and Evolution in Irish and British Populations ofEvolutionary applications · 2025Article
- Acute and chronic pesticide exposure trigger fundamentally different molecular responses in bumble bee brains.BMC biology · 2025Article
- Examining the Effects of Environment, Geography, and Elevation on Patterns of DNA Methylation Across Populations of Two Widespread Bumble Bee Species.Genome biology and evolution · 2024Article
- Genome-wide DNA methylation patterns in bumble bee (Bombus vosnesenskii) populations from spatial-environmental range extremes.Scientific reports · 2023Article
- Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels.Scientific reports · 2023Article
- Diesel exhaust particles alter gut microbiome and gene expression in the bumblebeeEcology and evolution · 2023Article
- Article
- Current Knowledge on Bee Innate Immunity Based on Genomics and Transcriptomics.International journal of molecular sciences · 2022Review
- Genomic Signatures of Recent Adaptation in a Wild Bumblebee.Molecular biology and evolution · 2022Article
- Review
- Effects of abiotic stresses on the expression of chitinase-like genes inFrontiers in physiology · 2022Article
- Reproductive Potential Impacts Body Maintenance Parameters and Global DNA Methylation in Honeybee Workers (Insects · 2021Article
- Chronic Effects of Imidacloprid on Honey Bee Worker Development-Molecular Pathway Perspectives.International journal of molecular sciences · 2021Review
- Review
- Bees and pesticides: the research impact and scientometrics relations.Environmental science and pollution research international · 2021Review
- Insecticide exposure affects intergenerational patterns of DNA methylation in the Colorado potato beetle,Evolutionary applications · 2021Article
- Impacts of Neonicotinoids on the Bumble Bees Bombus terrestris and Bombus impatiens Examined through the Lens of an Adverse Outcome Pathway Framework.Environmental toxicology and chemistry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Neonicotinoids are effective insecticides used on many important arable and horticultural crops. They are nicotinic acetylcholine receptor agonists which disrupt the function of insect neurons and cause paralysis and death. In addition to direct mortality, there are numerous sublethal effects of low doses of neonicotinoids on bees. We hypothesize that some of these large array of effects could be a consequence of epigenetic changes in bees induced by neonicotinoids. We compared whole methylome (BS-seq) and RNA-seq libraries of the brains of buff-tailed bumblebee Bombus terrestris workers exposed to field-realistic doses of the neonicotinoid imidacloprid to libraries from control workers. We found numerous genes which show differential expression between neonicotinoid-treated bees and control bees, but no differentially methylated cytosines in any context. We found CpG methylation to be focused mainly in exons and associated with highly expressed genes. We discuss the implications of our results for future legislation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.