SynthesisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.
Synthesis in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Implementation of computer simulation to assess flow diversion treatment outcomes: systematic review and meta-analysis.Journal of neurointerventional surgery · 2021Pooled it
- Preclinical extracranial aneurysm models for the study and treatment of brain aneurysms: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- Association of hypertension and blood pressure control with aneurysm wall enhancement in unruptured intracranial aneurysms: a multicenter propensity score-matched study.European radiology · 2026Article
- A transverse picoNewton force revealed in anisotropic Womersley flow.Scientific reports · 2026Article
- Patient-Specific Hemodynamic Simulation for Predicting Stroke Laterality in Cardiac Embolism.Journal of stroke · 2026Article
- The impact of stenting on hemodynamic environment of tortuous coronary artery: results derived from a numerical simulation model.Frontiers in bioengineering and biotechnology · 2026Article
- Computational studies on visceral artery lesions and aortic pathologies involving visceral branches: a comprehensive review for the clinician.Frontiers in cardiovascular medicine · 2026Review
- Ring-like (Donut-Shaped) Intracranial Aneurysms: A Warning Morphology of Mural Jet Flow and Pre-Rupture Instability.Diagnostics (Basel, Switzerland) · 2025Review
- Mechanisms of Intracranial Aneurysm Rupture: An Integrative Review of Experimental and Clinical Evidence.Journal of clinical medicine · 2025Review
- Hemodynamic differences between intracranial and extracranial dissecting aneurysms: An analysis of shear forces and their clinical implications.Neurosurgical review · 2025Article
- Endovascular structures of the basilar artery as forms of the basilar nonfusion spectrum.Scientific reports · 2025Article
- Modeling Techniques and Boundary Conditions in Abdominal Aortic Aneurysm Analysis: Latest Developments in Simulation and Integration of Machine Learning and Data-Driven Approaches.Bioengineering (Basel, Switzerland) · 2025Review
- Hemodynamic effects of stenosis with varying severity in different segments of the carotid artery using computational fluid dynamics.Scientific reports · 2025Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- Predictions of Small Intracranial Aneurysms' Rupture Risk with Ensemble Machine Learning Model (Super Learner): A Retrospective Study in Two Tertiary Hospitals in China.International journal of general medicine · 2025Article
- Aneurysm Formation at the Internal Carotid Artery Bifurcation Is Related to the Vascular Geometry of the Bifurcation.Brain sciences · 2024Article
- Advancements in Brain Aneurysm Management: Integrating Neuroanatomy, Physiopathology, and Neurosurgical Techniques.Medicina (Kaunas, Lithuania) · 2024Review
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Research square · 2024Article
- Transfer learning on physics-informed neural networks for tracking the hemodynamics in the evolving false lumen of dissected aorta.Nexus (New York, N.Y.) · 2024Article
- Angiography‑based quantitative flow ratio for functional assessment of intracranial atherosclerotic disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic using computational fluid dynamics (CFD), limited progress has been made towards understanding the complex physics and biology underlying IA pathophysiology. Guided by 1733 published papers, we review and discuss the contemporary IA hemodynamics paradigm established through two decades of IA CFD simulations. We have traced the historical origins of simplified CFD models which impede the progress of comprehending IA pathology. We also delve into the debate concerning the Newtonian fluid assumption used to represent blood flow computationally. We evidently demonstrate that the Newtonian assumption, used in almost 90% of studies, might be insufficient to describe IA hemodynamics. In addition, some fundamental properties of the Navier-Stokes equation are revisited in supplementary material to highlight some widely spread misconceptions regarding wall shear stress (WSS) and its derivatives. Conclusively, our study draws a roadmap for next-generation IA CFD models to help researchers investigate the pathophysiology of IAs.
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