ArticleTrends in hearing
Age-Related Hearing Loss Associations With Changes in Brain Morphology.
Article in Trends in hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Effect of hearing aids on cognitive functions in middle-aged and older adults with hearing loss: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Differences of Gradient Connectivity and Ventricle Volumes in Long-Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures.Human brain mapping · 2026Article
- [Current status and future perspectives on age-related hearing loss and cognitive impairment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- Short-term hearing aid use reduces auditory cortical responses to speech-in-noise listening among older adults with age-related hearing loss.Frontiers in aging neuroscience · 2026Article
- Individual differences in hearing decline predict region-specific brain and cognitive changes in healthy aging men.Frontiers in aging · 2026Article
- Exploring resting EEG correlates of age-related hearing difficulties.Frontiers in neuroscience · 2026Article
- Insights Into Stria Vascular Function, Stria Immunity, and Age-Related Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Brain volumetric analysis of elderly patients based on hearing levels quantified using FreeSurfer.Frontiers in neurology · 2025Article
- Executive Function Associations With Audibility-Adjusted Speech Perception in Noise.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Hearing Function Moderates Age-Related Differences in Brain Morphometry in the HCP Aging Cohort.Human brain mapping · 2024Article
- Sensory impairments associated with cognitive impairment among older adults in China: A community-based, 10-year prospective cohort study.Journal of global health · 2024Article
- Hearing function moderates age-related changes in brain morphometry in the HCP Aging cohort.bioRxiv : the preprint server for biology · 2024Article
- Digits-in-Noise Test as an Assessment Tool for Hearing Loss and Hearing Aids.Audiology research · 2024Article
- Sensorineural hearing loss and cognitive impairment: three hypotheses.Frontiers in aging neuroscience · 2024Review
- Association between sensation, perception, negative socio-psychological factors and cognitive impairment.Heliyon · 2023Article
- Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Listening with an Ageing Brain - a Cognitive Challenge.Laryngo- rhino- otologie · 2023Review
- Vision impairment, hearing impairment and functional Limitations of subjective cognitive decline: a population-based study.BMC geriatrics · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Age-related hearing loss has been associated with varied auditory cortex morphology in human neuroimaging studies. These findings have suggested that peripheral auditory system declines cause changes in brain morphology but could also be due to latent variables that affect the auditory periphery and brain. The current longitudinal study was designed to evaluate these explanations for pure-tone threshold and brain morphology associations. Thirty adults (mean age at Time 1 = 64.12 ± 10.32 years) were studied at two time points (average duration between visits = 2.62 ± 0.81 years). Small- to medium-effect size associations were observed between high-frequency pure-tone thresholds and auditory cortex gray matter volume at each time point. Although there were significant longitudinal changes in low- and high-frequency hearing measures and brain morphology, those longitudinal changes were not significantly correlated across participants. High-frequency hearing measures at Time 1 were significantly related to more lateral ventricle expansion, such that participants with higher measures exhibited larger increases in ventricle size. This ventricle effect was statistically independent of high-frequency hearing associations with auditory cortex morphology. Together, these results indicate that there are at least two mechanisms for associations between age-related hearing loss and brain morphology. Potential explanations for a direct hearing loss effect on brain morphology, as well as latent variables that likely affect both the inner ear and brain, are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.