Evidence map›Paper›PMID 31212896›Full record

ArticleJournal of clinical medicine2019

Response-Related Factors of Bone Marrow-Derived Mesenchymal Stem Cells Transplantation in Patients with Alcoholic Cirrhosis.

Haripriya Gupta, Gi Soo Youn, Sang Hak Han, Min Jea Shin, Sang Jun Yoon, Dae Hee Han, Na Young Lee, Dong Joon Kim, Soon Koo Baik, Ki Tae Suk

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Haripriya GuptaInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. phr.haripriya13@gmail.com.
Gi Soo YounInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. gisu0428@gmail.com.
Sang Hak HanDepartment of Pathology, Hallym University College of Medicine, Chuncheon 24253, Korea. drhsh74@hallym.or.kr.
Min Jea ShinInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. wehome3@hallym.ac.kr.
Sang Jun YoonInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. ysjtlhuman@gmail.com.
Dae Hee HanInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. eogmlgks@gmail.com.
Na Young LeeInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. na0lee0218@gmail.com.
Dong Joon KimInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. djkim@hallym.ac.kr.
Soon Koo BaikDepartment of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University, Wonju College of Medicine, Wonju 26426, Korea. baiksk@yonsei.ac.kr.
Ki Tae SukInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea. ktsuk@hallym.ac.kr.ORCID 0000-0002-9206-9245
Hallym University · KRYonsei University · KR

Funding

Hallym University Research Fund Hallym University Research FundHallym University Research Fund 2016 and 2017 HURF-2016-60 and HURF-2017-18Korea National Research Foundation NRF-2017R1A5A2015369 and NRF-2018M3A9F3020956
6 · The paper itself

Abstract

Liver cirrhosis leads to hepatic dysfunction and life-threatening conditions. Although the clinical efficacy of autologous bone marrow-derived mesenchymal stem cells (BM-MSC) transplantation in alcoholic cirrhosis (AC) was demonstrated, the relevant mechanism has not been elucidated. We aimed to identify the predictive factors and gene/pathways for responders after autologous BM-MSC transplantation. Fifty-five patients with biopsy-proven AC underwent autologous BM-MSC transplantation. The characteristics of responders who showed improvement in fibrosis score (≥1) after transplantation were compared with those of non-responders. BM-MSCs were analyzed with cDNA microarrays to identify gene/pathways that were differentially expressed in responders. Thirty-three patients (66%) were responders. A high initial Laennec score (

Indexed as

bone marrowcharacteristicscirrhosisliver regenerationmesenchymal stem cells

Identifiers

PMID31212896
PMCPMC6616969
OpenAlexW2948345862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.