ArticleJournal of clinical medicine2019
Salivary Redox Biomarkers in Different Stages of Dementia Severity.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis.Alzheimer's research & therapy · 2022Pooled it
- Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?Oxidative medicine and cellular longevity · 2020Trial
- Capturing silent oxidative stress in early Alzheimer's disease: prediction of CSF biomarkers from sleep qEEG data.GeroScience · 2026Article
- Protein glycoxidation in neuropsychiatric disorders-from basic research to clinical practice.Redox biology · 2026Review
- Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19.Scientific reports · 2024Article
- Finding biomarkers of experience in animals.Journal of animal science and biotechnology · 2024Review
- Oxidative imbalance as a co-player in jaw functional limitations and biopsychosocial profile in patients with temporomandibular disorder-myofascial pain with referral.Frontiers in neurology · 2024Article
- Could circulating biomarkers of nitrosative stress and protein glycoxidation be useful in patients with gastric cancer?Frontiers in oncology · 2023Article
- Diagnostic significance and utility of circulating redox biomarkers in patients with gastric cancer - preliminary study.Annals of medicine · 2023Article
- Biomarkers in Oral Fluids as Diagnostic Tool for Psoriasis.Life (Basel, Switzerland) · 2022Review
- Novel impacts of saliva with regard to oral health.The Journal of prosthetic dentistry · 2022Review
- May the Nitrosative and Carbonyl Stress Promote Inflammation in Patients with Colorectal Cancer?Journal of inflammation research · 2022Article
- Regulation of Oxidative Stress by Long Non-coding RNAs in Central Nervous System Disorders.Frontiers in molecular neuroscience · 2022Review
- Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics.Frontiers in immunology · 2022Article
- Oxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging?Journal of inflammation research · 2022Article
- Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer's disease.Scientific reports · 2021Article
- Evaluation of salivary thiobarbituric acid reactive substances, total protein, and pH in children with various degrees of early childhood caries: a case-control study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Salivary cytokine profile in patients with ischemic stroke.Scientific reports · 2021Article
- The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer's Disease and Parkinson's Disease.Diagnostics (Basel, Switzerland) · 2021Review
- Salivary Gland Dysfunction in Patients with Chronic Heart Failure Is Aggravated by Nitrosative Stress, as Well as Oxidation and Glycation of Proteins.Biomolecules · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
This study is the first to evaluate oxidative stress biomarkers in saliva/blood of patients with varying degrees of dementia progression. The study included 50 healthy controls and 50 dementia patients divided into two groups: those with mild and moderate dementia (MMSE 11-23) and patients suffering from severe dementia (MMSE 0-10). Cognitive functions of the subjects were assessed using the Mini Mental State Examination (MMSE). Enzymatic and non-enzymatic antioxidants, oxidative damage products and protein glycoxidative modifications were determined in non-stimulated (NWS) and stimulated (SWS) saliva as well as erythrocyte/plasma samples. Generally, in dementia patients, we observed the depletion of antioxidant defences leading to oxidative and glycoxidative damage in NWS, SWS and blood samples. Both salivary and blood oxidative stress increased with the severity of the disease, and correlated with a decrease of cognitive functions. Interestingly, in dementia patients, reduced glutathione (GSH) in NWS correlated not only with the severity of dementia, but also with GSH concentration in the plasma. In receiver operating characteristic (ROC) analysis, we have demonstrated that salivary GSH clearly distinguishes patients with severe dementia from those suffering from mild or moderate dementia (area under the curve (AUC) = 1). Therefore, salivary GSH can be used as a non-invasive biomarker of cognitive impairment.
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