Evidence map›Paper›PMID 31212795›Full record

ArticleMarine drugs2019

Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin.

Wallace S Abreu, Paulo A G Soares, Juliana M Motta, Eliene O Kozlowski, Felipe C O B Teixeira, Mariana A Soares, Lubor Borsig, Paulo A S Mourão, Mauro S G Pavão

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Wallace S AbreuPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. wallace.s.abreu@gmail.com.
Paulo A G SoaresPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. paulogsoares@hucff.ufrj.br.
Juliana M MottaPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. jmotta@bioqmed.ufrj.br.
Eliene O KozlowskiPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
Felipe C O B TeixeiraPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. felipebrito7@gmail.com.
Mariana A SoaresPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. mariana.alsoares@gmail.com.ORCID 0000-0003-2935-4075
Lubor BorsigInstitute of Physiology, University of Zurich and Zurich Center for Integrative Human Physiology, 8057 Zurich, Switzerland. lborsig@access.uzh.ch.
Paulo A S MourãoPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. pmourao@hucff.ufrj.br.
Mauro S G PavãoPrograma de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil. mpavao@hucff.ufrj.br.ORCID 0000-0002-1336-4271
Universidade Federal do Rio de Janeiro · BRUniversity of Zurich · CH

Funding

Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) There is no grant number
6 · The paper itself

Abstract

Heparin or highly sulfated heparan sulfate (HS) has been described in different invertebrates. In ascidians (Chordata-Tunicata), these glycosaminoglycans occur in intracellular granules of oocyte accessory cells and circulating basophil-like cells, resembling mammalian mast cells and basophils, respectively. HS is also a component of the basement membrane of different ascidian organs. We have analyzed an HS isolated from the internal organs of the ascidian

Indexed as

AdenocarcinomaAnimalsAnticoagulantsCell Line, TumorColonColonic NeoplasmsGlucuronatesGlucuronic AcidGlycosaminoglycansHeparan SulfateHeparinHumansP-SelectinUrochordataAnticoagulantsGlucuronatesGlucuronic Acidglucuronic acid 2-sulfateGlycosaminoglycansHeparan SulfateHeparinP-SelectinSELP protein, humanascidian glycosaminoglycanscancercoagulationheparan sulfatemarine biologynuclear magnetic resonanceP-selectin

Identifiers

PMID31212795
PMCPMC6627333
OpenAlexW2952806601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.