Evidence map›Paper›PMID 31212631›Full record

ArticleViruses2019

Development of American-Lineage Influenza H5N2 Reassortant Vaccine Viruses for Pandemic Preparedness.

Po-Ling Chen, Alan Yung-Chih Hu, Chun-Yang Lin, Tsai-Chuan Weng, Chia-Chun Lai, Yu-Fen Tseng, Ming-Chu Cheng, Min-Yuan Chia, Wen-Chin Lin, Chia-Tsui Yeh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Po-Ling ChenNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. letitia@nhri.org.tw.
Alan Yung-Chih HuNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. alanhu@nhri.org.tw.
Chun-Yang LinNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. grayingaries@outlook.com.ORCID 0000-0002-3064-0178
Tsai-Chuan WengNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. wtc@nhri.org.tw.
Chia-Chun LaiNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. laicc2@nhri.org.tw.
Yu-Fen TsengNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. yufents@gmail.com.
Ming-Chu ChengDepartment of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. mccheng@mail.npust.edu.tw.
Min-Yuan ChiaNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. chiaminyuan@dragon.nchu.edu.tw.
Wen-Chin LinInstitute of Preventive Medicine, National Defence Medical Centre, Taipei 23742, Taiwan. spps057@gmail.com.
Chia-Tsui YehInstitute of Preventive Medicine, National Defence Medical Centre, Taipei 23742, Taiwan. yyhome@mail.ndmctsgh.edu.tw.
Ih-Jen SuNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. suihjen0704@stust.edu.tw.
Min-Shi LeeNational Institution of Infectious Diseases and Vaccinology, National Health Research Institutes (NHRI), Zhunan, Miaoli 35053, Taiwan. minshi@nhri.org.tw.
National Health Research Institutes · TWNational Defense Medical Center · TWNational Chung Hsing University · TWNational Pingtung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel low-pathogenic avian influenza (LPAI) H5N2 viruses hit poultry farms in Taiwan in 2003, and evolved into highly pathogenic avian influenza (HPAI) viruses in 2010. These viruses are reassortant viruses containing HA and NA genes from American-lineage H5N2 and six internal genes from local H6N1 viruses. According to a serological survey, the Taiwan H5N2 viruses can cause asymptomatic infections in poultry workers. Therefore, a development of influenza H5N2 vaccines is desirable for pandemic preparation. In this study, we employed reverse genetics to generate a vaccine virus having HA and NA genes from A/Chicken/CY/A2628/2012 (E7, LPAI) and six internal genes from a Vero cell-adapted high-growth H5N1 vaccine virus (Vero-15). The reassortant H5N2 vaccine virus, E7-V15, presented high-growth efficiency in Vero cells (512 HAU, 10

Indexed as

AnimalsAntibodies, ViralChlorocebus aethiopsFerretsHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H5N2 SubtypeInfluenza, HumanInfluenza VaccinesNeuraminidaseReassortant VirusesReverse GeneticsTaiwanTreatment OutcomeVaccines, InactivatedVero CellsAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesNA protein, influenza A virusNeuraminidaseVaccines, InactivatedViral ProteinsAmerican-lineage H5N2 vaccineAmerican-lineage reassortant influenza virusesPandemic preparedness

Identifiers

PMID31212631
PMCPMC6631248
OpenAlexW2950729600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.