ArticleNeurobiology of disease2019
MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy.
Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- FMR1 gene therapy restores translationally relevant phenotypes in a mouse model for fragile X syndrome.Gene therapy · 2026Article
- Central toxic effects of an antitumoral bufadienolide: In silico targets and in vivo findings.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Ion channel and biophysical properties of extracellular vesicles.The Journal of biological chemistry · 2026Review
- Scientific Symposium: Biological Sex as a Factor in Epilepsy Research and Treatment.Epilepsy currents · 2026Article
- How Soon is Soon Enough? Consideration of Timing and Disease Etiology for microRNAs in Epilepsy.Epilepsy currents · 2025Review
- Review
- Mir324 knockout regulates the structure of dendritic spines and impairs hippocampal long-term potentiation.Scientific reports · 2023Article
- Further advances in epilepsy.Journal of neurology · 2023Review
- Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice.Journal of molecular neuroscience : MN · 2023Article
- Age-dependent regulation of dendritic spine density and protein expression in Mir324 KO mice.Research square · 2023Article
- MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury.Molecular psychiatry · 2023Review
- circRNA fromInternational journal of molecular sciences · 2023Article
- MiR-324-5p inhibition after intrahippocampal kainic acid-inducedFrontiers in neurology · 2023Article
- Identification of key potassium channel genes of temporal lobe epilepsy by bioinformatics analyses and experimental verification.Frontiers in neurology · 2023Article
- The mechanism of sudden unexpected death in epilepsy: A mini review.Frontiers in neurology · 2023Review
- Identification of Ion Channel-Related Genes and miRNA-mRNA Networks in Mesial Temporal Lobe Epilepsy.Frontiers in genetics · 2022Article
- A review on the role of miRNA-324 in various diseases.Frontiers in genetics · 2022Review
- Increased hippocampal excitability in miR-324-null mice.Scientific reports · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
Epilepsy is often associated with altered expression or function of ion channels. One example of such a channelopathy is the reduction of A-type potassium currents in the hippocampal CA1 region. The underlying mechanisms of reduced A-type channel function in epilepsy are unclear. Here, we show that inhibiting a single microRNA, miR-324-5p, which targets the pore-forming A-type potassium channel subunit Kv4.2, selectively increased A-type potassium currents in hippocampal CA1 pyramidal neurons in mice. Resting membrane potential, input resistance and other potassium currents were not altered. In a mouse model of acquired chronic epilepsy, inhibition of miR-324-5p reduced the frequency of spontaneous seizures and interictal epileptiform spikes supporting the physiological relevance of miR-324-5p-mediated control of A-type currents in regulating neuronal excitability. Mechanistic analyses demonstrated that microRNA-induced silencing of Kv4.2 mRNA is increased in epileptic mice leading to reduced Kv4.2 protein levels, which is mitigated by miR-324-5p inhibition. By contrast, other targets of miR-324-5p were unchanged. These results suggest a selective miR-324-5p-dependent mechanism in epilepsy regulating potassium channel function, hyperexcitability and seizures.
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