ArticleDevelopmental cell2019
Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation.
Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- 3D epithelial cell topology tunes signaling range to promote precise patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis.Biology open · 2025Article
- Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly.Development (Cambridge, England) · 2023Article
- Mechanochemical feedback loops in contact-dependent fate patterning.Current opinion in systems biology · 2023Review
- Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo.EMBO reports · 2022Article
- Extracellular Vesicles and Membrane Protrusions in Developmental Signaling.Journal of developmental biology · 2022Review
- Dynamic switching of lateral inhibition spatial patterns.Journal of the Royal Society, Interface · 2022Article
- Notch controls the cell cycle to define leader versus follower identities during collective cell migration.eLife · 2022Article
- A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis.Journal of cell science · 2022Article
- Establishing neuronal polarity: microtubule regulation during neurite initiation.Oxford open neuroscience · 2022Review
- A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.Molecular systems biology · 2021Article
- Delta-Notch Signaling: The Long and The Short of a Neuron's Influence on Progenitor Fates.Journal of developmental biology · 2020Review
- Protrusion-Mediated Signaling Regulates Patterning of the Developing Nervous System.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
During early spinal cord development, neurons of particular subtypes differentiate with a sparse periodic pattern while later neurons differentiate in the intervening space to eventually produce continuous columns of similar neurons. The mechanisms that regulate this spatiotemporal pattern are unknown. In vivo imaging in zebrafish reveals that differentiating spinal neurons transiently extend two long protrusions along the basal surface of the spinal cord before axon initiation. These protrusions express Delta protein, consistent with the hypothesis they influence Notch signaling at a distance of several cell diameters. Experimental reduction of Laminin expression leads to smaller protrusions and shorter distances between differentiating neurons. The experimental data and a theoretical model support the proposal that neuronal differentiation pattern is regulated by transient basal protrusions that deliver temporally controlled lateral inhibition mediated at a distance. This work uncovers a stereotyped protrusive activity of newborn neurons that organize long-distance spatiotemporal patterning of differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.