ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Infection-induced endothelial amyloids impair memory.
Abstract read
In one paragraph
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
26 citing papers in PubMed.
- Pathological or preventative? Amyloid-β as an effector of innate immunity.Infection and immunity · 2026Review
- Lung endothelial cytopathic tau is sufficient to impair long-term potentiation during infection.American journal of respiratory cell and molecular biology · 2026Article
- Barrier breakdown: lung-brain crosstalk in systemic inflammation.Journal of neuroinflammation · 2026Review
- Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction.Communications biology · 2026Article
- Resolving cognitive heterogeneity in white matter hyperintensities through integrated analyses of microbiome, metabolome, and brain glymphatic function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer's Disease?Neuroscience bulletin · 2025Review
- Alzheimer's Disease as Type 3 Diabetes: Understanding the Link and Implications.International journal of molecular sciences · 2024Review
- Article
- The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP.Angiogenesis · 2024Article
- cUMP elicits interendothelial gap formation duringAmerican journal of physiology. Lung cellular and molecular physiology · 2024Article
- Lung endothelium, tau, and amyloids in health and disease.Physiological reviews · 2024Review
- Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study.PloS one · 2024Observational
- Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Infection promotes Ser-214 phosphorylation important for generation of cytotoxic tau variants.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.Journal of neuroinflammation · 2023Article
- Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice.Research square · 2023Article
- Microglia activation in the mPFC mediates anxiety-like behaviors caused by Staphylococcus aureus strain USA300.Brain and behavior · 2022Article
- COVID-19 and Long-Term Outcomes: Lessons from Other Critical Care Illnesses and Potential Mechanisms.American journal of respiratory cell and molecular biology · 2022Article
- New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.American journal of respiratory cell and molecular biology · 2022Article
- Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
15 authors.
Ron BalczonDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, USA.
Jean-Francois PittetDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Brant M WagenerDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Stephen A MoserDepartment of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Sarah VothCenter for Lung Biology, University of South Alabama, Mobile, Alabama, USA.
Charles V VorheesDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Michael T WilliamsDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
James P BridgesDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Diego F AlvarezCenter for Lung Biology, University of South Alabama, Mobile, Alabama, USA.
Anna KolotevaDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, USA.
Yuanyuan XuDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, USA.
Xiang-Ming ZhaDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, USA.
Jonathon P AudiaCenter for Lung Biology, University of South Alabama, Mobile, Alabama, USA.
Troy StevensCenter for Lung Biology, University of South Alabama, Mobile, Alabama, USA.
Mike T LinCenter for Lung Biology, University of South Alabama, Mobile, Alabama, USA.
Funding
T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F. · 2001 to 2022
$34.6MNosocomial pneumonias impair cognitive functionR01HL140182 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Mike Lin · 2018 to 2026
$4.9MStore-operated calcium entry: lung endothelial permeabilityR37HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2010 to 2019
$3.9MStore Operated Calcium Entry: Lung Endothelial PermeabilityR01HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 1998 to 2009
$3.0MTraining in Cell Signaling and Lung PathobiologyT32HL076125 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI RICH, THOMAS C, STEVENS, TROY · 2004 to 2018
$2.7MCaspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0MNeuroprotective role of OGR1 in brain ischemiaR01NS102495 · NINDS · UNIVERSITY OF SOUTH ALABAMA · PI ZHA, XIANGMING · 2017 to 2022
$1.8MSoluble adenylyl cyclases and Lung Endothelial PermeabilityR01HL135003 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2017 to 2017
$379kCytotoxic Lung Endothelial AmyloidsF31HL147512 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI VOTH, SARAH B. · 2019 to 2020
$38kNHLBI NIH HHS F31 HL147512NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL060024NHLBI NIH HHS R01 HL118334NHLBI NIH HHS R01 HL135003NHLBI NIH HHS R01 HL140182NHLBI NIH HHS R37 HL060024NHLBI NIH HHS T32 HL076125NINDS NIH HHS R01 NS102495
Abstract
Patients with nosocomial pneumonia exhibit elevated levels of neurotoxic amyloid and tau proteins in the cerebrospinal fluid (CSF).
Indexed as
AmyloidAnimalsEndothelium, VascularFearFemaleHumansLearningLungMaleMemory DisordersMiceMice, Inbred C57BLNeuronal PlasticityPseudomonas aeruginosaPseudomonas Infectionstau ProteinsAmyloidtau Proteinscerebrospinal fluiddementiadepressionlearningnosocomial pneumonia
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.