ArticlePloS one2019
Differences in biological behaviors between young and elderly patients with colorectal cancer.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Pooled it
- Impact of adjuvant chemotherapy on survival after pathological complete response in rectal cancer: a meta-analysis of 31,558 patients.International journal of colorectal disease · 2024Pooled it
- Geographic and Ethnic Variation in Early-onset Colorectal Cancer: A Contemporary Scoping Review of Epidemiologic, Molecular, and Survival Patterns.Journal of gastrointestinal cancer · 2026Article
- Euscaphic Acid from Rosa roxburghii Tratt Exerts Anti-colorectal Cancer Activity by Inducing Mitochondrial Apoptosis through ROS/MAPK Pathway.Chinese journal of integrative medicine · 2026Article
- Anemia-Related Red Flags as Distinctive Early Indicators for Colorectal Cancer Diagnosis in Older Adults.Journal of clinical medicine · 2026Article
- Extent of cancer at the time of diagnosis in older adults: a cohort of a Chilean cancer insurance program (2018-2022).Ecancermedicalscience · 2026Article
- Article
- Clinicopathological Characteristics and Synchronous Lesions in Colorectal Cancer: A Single-Center Retrospective Colonoscopy Study.Journal of clinical medicine · 2025Article
- Targeted Therapy and Immunotherapy in Elderly Patients with Metastatic Colorectal Cancer.Current treatment options in oncology · 2025Review
- Evolution of Colorectal Cancer Trends and Treatment Outcomes: A Comprehensive Retrospective Analysis (2019-2023) in West Kazakhstan.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Advantage of log odds of positive lymph nodes in prognostic evaluation of patients with early-onset colon cancer.World journal of gastrointestinal surgery · 2023Article
- Patients younger than 40 years with colorectal cancer have a similar prognosis to older patients.International journal of colorectal disease · 2023Article
- Retrospective Cohort Analysis of the Effect of Age on Lymph Node Harvest, Positivity, and Ratio in Colorectal Cancer.Cancers · 2022Article
- Clinical characteristics of patients in their forties who underwent surgical resection for colorectal cancer in Korea.World journal of gastroenterology · 2021Article
- Article
- Fluoropyrimdine therapy induced alterations in interleukins expression in colorectal cancer patients.International journal of immunopathology and pharmacologyArticle
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the differences in biological behaviors of sporadic colorectal cancer (CRC) between young and elderly patients. CRC is a common cancer, with a mean age at onset of > 65 years. However, recent reports indicate increasing rates in younger populations. The biological behaviors of sporadic CRC in elderly patients could differ from those in young patients.
methodsBetween September 2007 and August 2012, we selected 723 CRC patients from our institution. The patients were divided into Group Y (n = 127, aged ≤50 years) and Group O (n = 596, aged >50 years). The clinicopathologic and oncologic outcomes in the two groups were compared.
resultsGroup Y tumors were characterized by higher incidences of mucin production (13.4% vs. 6.7%; P = 0.017), high microsatellite instability (MSI-H) (19.8% vs. 5.2%; P < 0.001), and N2 stage (32.3% vs. 22.1%; P = 0.020) than those in Group O. The recurrence rates were similar in both groups (14.9% vs. 17.3%; P = 0.665). The 5-year overall survival and disease-free survival did not differ. Multivariate analysis indicated that cellular differentiation and pathologic stage were significant prognostic factors for 5-year overall survival.
conclusionAlthough age was not a prognostic factor for overall survival and young patients did not show a worse prognosis, there were differences in mucin production, MSI-H, and N2 stage between the two groups. Further studies are needed to clarify the clinical and biological characteristics of CRC, improve its treatment strategies, and promote better outcomes in young patients.
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