ArticlePloS one2019
Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- The impact of parasitic diseases on dromedary camel (Frontiers in veterinary science · 2025Review
- Impacts of dietary fat on multi tissue gene expression in the desert-adapted cactus mouse.The Journal of experimental biology · 2024Article
- Effects of long-term dehydration and quick rehydration on the camel kidney: pathological changes and modulation of the expression of solute carrier proteins and aquaporins.BMC veterinary research · 2024Article
- The multi-tissue gene expression and physiological responses of water deprived Peromyscus eremicus.BMC genomics · 2024Article
- When the tap runs dry: The multi-tissue gene expression and physiological responses of water deprivedbioRxiv : the preprint server for biology · 2024Article
- Bioinformatics for Prohormone and Neuropeptide Discovery.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Peptidomics.Nature reviews. Methods primers · 2023Article
- Recent advances in mass spectrometry analysis of neuropeptides.Mass spectrometry reviews · 2023Review
- Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel.Communications biology · 2022Article
- Changes in Neuropeptide Prohormone Genes amongVeterinary sciences · 2022Article
- Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation.Communications biology · 2021Article
- Nucleotide diversity of functionally different groups of immune response genes in Old World camels based on newly annotated and reference-guided assemblies.BMC genomics · 2020Article
- Old World camels in a modern world - a balancing act between conservation and genetic improvement.Animal genetics · 2019Review
- Improving Illumina assemblies with Hi-C and long reads: An example with the North African dromedary.Molecular ecology resources · 2019Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 8 countries.
Funding
Abstract
The "ship" of the Arabian and North African deserts, the one-humped dromedary camel (Camelus dromedarius) has a remarkable capacity to survive in conditions of extreme heat without needing to drink water. One of the ways that this is achieved is through the actions of the antidiuretic hormone arginine vasopressin (AVP), which is made in a specialised part of the brain called the hypothalamo-neurohypophyseal system (HNS), but exerts its effects at the level of the kidney to provoke water conservation. Interestingly, our electron microscopy studies have shown that the ultrastructure of the dromedary HNS changes according to season, suggesting that in the arid conditions of summer the HNS is in an activated state, in preparation for the likely prospect of water deprivation. Based on our dromedary genome sequence, we have carried out an RNAseq analysis of the dromedary HNS in summer and winter. Amongst the 171 transcripts found to be significantly differentially regulated (>2 fold change, p value <0.05) there is a significant over-representation of neuropeptide encoding genes, including that encoding AVP, the expression of which appeared to increase in summer. Identification of neuropeptides in the HNS and analysis of neuropeptide profiles in extracts from individual camels using mass spectrometry indicates that overall AVP peptide levels decreased in the HNS during summer compared to winter, perhaps due to increased release during periods of dehydration in the dry season.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.