Evidence map›Paper›PMID 31211618›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Alterations of skeletal muscle bioenergetics in a mouse with F508del mutation leading to a cystic fibrosis-like condition.

Nicola Lai, Chinna Kummitha, Mitchell Drumm, Charles Hoppel

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicola LaiDepartment of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia.ORCID 0000-0002-3436-289X
Chinna KummithaDepartment of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia.
Mitchell DrummDepartment of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Charles HoppelDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Case Western Reserve University · US

Funding

Translational Research in Cystic FibrosisP30DK027651 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DRUMM, MITCHELL L · 1986 to 2014
$15.6M
Systems Biology Investigation of Muscle Exercise Metabolism in DiabetesK25AR057206 · NIAMS · OLD DOMINION UNIVERSITY · PI LAI, NICOLA · 2011 to 2015
$593k
NIAMS NIH HHS K25 AR057206NIDDK NIH HHS P30 DK027651
6 · The paper itself

Abstract

High energy expenditure is reported in cystic fibrosis (CF) animal models and patients. Alterations in skeletal muscle oxidative capacity, fuel utilization, and the creatine kinase-phosphocreatine system suggest mitochondrial dysfunction. Studies were performed on congenic C57BL/6J and F508del (

Indexed as

AnimalsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEnergy MetabolismFemaleMaleMiceMice, Inbred C57BLMice, Inbred CFTRMice, TransgenicMitochondria, MuscleMuscle, SkeletalOxidative PhosphorylationOxidative StressPhysical Conditioning, AnimalSequence DeletionCftr protein, mouseCystic Fibrosis Transmembrane Conductance Regulatorenergy metabolisminterfibrillaroxidative phosphorylationrespirationsubsarcolemmal

Identifiers

PMID31211618
PMCPMC6732463
OpenAlexW2951664686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.