ArticleJournal of cellular and molecular medicine2019
Additive antidepressant-like effects of fasting with β-estradiol in mice.
Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
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- Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: A Comprehensive Review of Scientific Data.International journal of molecular sciences · 2025Review
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- Examination of Gender Differences in Depression, Relationship Satisfaction, and Problematic Pornography Use Among Romanian Gay Men and Lesbian Women.International journal of sexual health : official journal of the World Association for Sexual Health · 2024Article
- Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms.Molecules (Basel, Switzerland) · 2023Review
- Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice.Neural regeneration research · 2023Article
- Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like Effects via Dopamine D2 Receptor Activation in Ovariectomized Mice.The international journal of neuropsychopharmacology · 2023Article
- Article
- Quality of Life in Multiple Sclerosis Patients: Influence of Gender, Age and Marital Status.Materia socio-medica · 2022Article
- Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.Cell proliferation · 2020Review
- Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit.Neural plasticity · 2020Review
- Gender Differences in Depression: Evidence From Genetics.Frontiers in genetics · 2020Review
- Additive antidepressant-like effects of fasting with β-estradiol in mice.Journal of cellular and molecular medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our recent study has shown that acute fasting produces antidepressant-like effects in male mice. However, there is little evidence regarding the antidepressant-like effects of acute fasting in female mice. Moreover, it is not yet clear whether estrogen produces additive effects with acute fasting. Therefore, this study aims to investigate the antidepressant-like effects of acute fasting plus estrogen treatment. In this study, the acute fasting produced antidepressant-like effects in female mice and the antidepressant-like effects of 9 hours fasting with those of β-estradiol (E2) were additive. Activity of the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-brain-derived neurotrophic factor (BDNF) pathway in the prefrontal cortex (PFC) and hippocampus (HP) was increased, as well as neurogenesis in the subgranular zone of the hippocampus. Serum ghrelin and estrogen were also increased by fasting plus E2. Furthermore, RNA-seq analysis indicated that fasting and E2 co-regulate similar gene expression pathways, underlying similar neurological functions. Taken together, these data suggest that E2 produces additive antidepressant-like effects with fasting by activating the CREB-BDNF pathway in the PFC and HP. Genome-wide transcriptome mapping suggests that fasting may be used as an adjunct to estrogen replacement therapy for the treatment of depression associated with reduced estrogen function.
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Registered trials
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