ArticleJournal of experimental botany2019
NF-YC12 is a key multi-functional regulator of accumulation of seed storage substances in rice.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 130 citations in OpenAlex.
- The OsMYB4 transcription factor enables coordinated improvement of grain yield and quality in rice.Nature communications · 2026Article
- Decoding heat-induced chalkiness in rice: molecular mechanisms, genetic networks, and mitigation strategies for climate resilience.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- The Mechanisms of Changes in Storage Substances and Hormone Levels During Artificial Aging of Different Varieties of Perilla.Current issues in molecular biology · 2026Article
- Superior alleles ofNational science review · 2026Article
- Three transcription factors, OsNF-YC8, OsNF-YC9, and OsNF-YC10, function redundantly to promote amylopectin synthesis by activating SBE3 expression in rice endosperm.Plant communications · 2026Article
- Genetic Determinants and Breeding Strategies for Rice Cooking and Eating Quality: A Comprehensive Review.Plant biotechnology journal · 2026Review
- Nuclear factor OsNF-YC5 regulates grain size and quality in rice.Plant molecular biology · 2026Article
- From Structure to Function of Promoters and 5'UTRs in Maize.International journal of molecular sciences · 2026Review
- Genome-wide identification of NF-Y family in Carya illinoinensis and CiNF-YC6 role in fatty acid biosynthesis.Plant cell reports · 2025Article
- Article
- Nuclear factor-Y transcription factors in crops: Biological roles, regulation, and breeding applications.Plant communications · 2025Review
- A Natural Major Module Confers the Trade-Off between Phenotypic Mean and Plasticity of Grain Chalkiness in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genetic basis of grain protein and fat contents preliminarily decoded in a foxtail millet biparental recombinant inbred line population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Transcriptome-Based Identification of Novel Transcription Factors Regulating Seed Storage Proteins in Rice.Plants (Basel, Switzerland) · 2025Article
- The Endosperm-Specific GenePlants (Basel, Switzerland) · 2025Article
- Unique starch biosynthesis pathways in wild rice revealed by multi-omics analyses.Plant biotechnology journal · 2025Article
- Creating a SuperiorFoods (Basel, Switzerland) · 2025Article
- Carbohydrate flow during grain filling: Phytohormonal regulation and genetic control in rice (Oryza sativa).Journal of integrative plant biology · 2025Review
- A novel transcription factor OsMYB73 affects grain size and chalkiness by regulating endosperm storage substances' accumulation-mediated auxin biosynthesis signalling pathway in rice.Plant biotechnology journal · 2025Article
- Mining of Root-Specific Expression Genes and Their Core Cis-Regulatory Elements in Plants.International journal of molecular sciences · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Starch and storage proteins, the primary storage substances of cereal endosperm, are a major source of food for humans. However, the transcriptional regulatory networks of the synthesis and accumulation of storage substances remain largely unknown. Here, we identified a rice endosperm-specific gene, NF-YC12, that encodes a putative nuclear factor-Y transcription factor subunit C. NF-YC12 is expressed in the aleurone layer and starchy endosperm during grain development. Knockout of NF-YC12 significantly decreased grain weight as well as altering starch and protein accumulation and starch granule formation. RNA-sequencing analysis revealed that in the nf-yc12 mutant genes related to starch biosynthesis and the metabolism of energy reserves were enriched in the down-regulated category. In addition, starch and protein contents in seeds differed between NF-YC12-overexpression lines and the wild-type. NF-YC12 was found to interact with NF-YB1. ChIP-qPCR and yeast one-hybrid assays showed that NF-YC12 regulated the rice sucrose transporter OsSUT1 in coordination with NF-YB1 in the aleurone layer. In addition, NF-YC12 was directly bound to the promoters of FLO6 (FLOURY ENDOSPERM6) and OsGS1;3 (glutamine synthetase1) in developing endosperm. This study demonstrates a transcriptional regulatory network involving NF-YC12, which coordinates multiple pathways to regulate endosperm development and the accumulation of storage substances in rice seeds.
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