ArticleEuropean heart journal. Cardiovascular Imaging2020
Predictors of 18F-sodium fluoride uptake in patients with stable coronary artery disease and adverse plaque features on computed tomography angiography.
Article in European heart journal. Cardiovascular Imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
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- From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026Review
- Pharmacotherapeutic Strategies for Fine Particulate Matter-Induced Lung and Cardiovascular Damage: Marketed Drugs, Traditional Chinese Medicine, and Biological Agents.Cardiovascular toxicology · 2025Review
- Emerging Applications of Positron Emission Tomography in Coronary Artery Disease.Journal of personalized medicine · 2025Review
- Sex differences in coronary atherosclerotic plaque activity usingEuropean journal of nuclear medicine and molecular imaging · 2024Article
- Noninvasive Atherosclerotic Phenotyping: The Next Frontier into Understanding the Pathobiology of Coronary Artery Disease.Current atherosclerosis reports · 2024Review
- Computed Tomography Angiography Characteristics of Thin-Cap Fibroatheroma in Patients With Diabetes.Journal of the American Heart Association · 2024Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The Role of Positron Emission Tomography in Advancing the Understanding of the Pathogenesis of Heart and Vascular Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Advanced Cardiac Imaging in the Assessment of Aortic Stenosis.Journal of cardiovascular development and disease · 2023Review
- AorticJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Does Coronary Plaque Morphology Matter Beyond Plaque Burden?Current atherosclerosis reports · 2023Review
- Pericoronary adipose tissue CT attenuation in coronary artery plaque inflammation.Heart (British Cardiac Society) · 2023Article
- Advances in the Assessment of Coronary Artery Disease Activity with PET/CT and CTA.Tomography (Ann Arbor, Mich.) · 2023Review
- Clinical value of perivascular fat attenuation index and computed tomography derived fractional flow reserve in identification of culprit lesion of subsequent acute coronary syndrome.Frontiers in cardiovascular medicine · 2023Article
- Artificial intelligence-based quantification of cardiac 18F-sodium fluoride uptake.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Advances in positron emission tomography tracers related to vascular calcification.Annals of nuclear medicine · 2022Review
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Authors and funding
14 authors at 3 institutions in 4 countries.
Funding
Abstract
aimsIn patients with stable coronary artery disease (CAD) and high-risk plaques (HRPs) on coronary computed tomography angiography (CTA), we sought to define qualitative and quantitative CTA predictors of abnormal coronary 18F-sodium fluoride uptake (18F-NaF) by positron emission tomography (PET). METHODS AND
resultsPatients undergoing coronary CTA were screened for HRP. Those who presented with ≥3 CTA adverse plaque features (APFs) including positive remodelling; low attenuation plaque (LAP, <30 HU), spotty calcification; obstructive coronary stenosis ≥50%; plaque volume >100 mm3 were recruited for 18F-NaF PET. In lesions with stenosis ≥25%, quantitative plaque analysis and maximum 18F-NaF target to background ratios (TBRs) were measured. Of 55 patients, 35 (64%) manifested coronary 18F-NaF uptake. Of 68 high-risk lesions 49 (70%) had increased PET tracer activity. Of the APFs, LAP had the highest sensitivity (39.4%) and specificity (98.3%) for predicting 18F-NaF uptake. TBR values were higher in lesions with LAP compared to those without [1.6 (1.3-1.8) vs. 1.1 (1.0-1.3), P = 0.01]. On adjusted multivariable regression analysis, LAP (both qualitative and quantitative) was independently associated with plaque TBR [LAP qualitative: β = 0.47, 95% confidence interval (CI) 0.30-0.65; P < 0.001] and (LAP volume: β = 0.20 per 10 mm3, 95% CI 0.13-0.27; P < 0.001).
conclusionIn stable CAD patients with HRP, LAP is predictive of 18F-NaF coronary uptake, but 18F-NaF is often seen in the absence of LAP. If 18F-NaF uptake is shown to be associated with adverse outcomes and becomes clinically used, the presence of LAP may define patients who would not benefit from the added testing.
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