ArticleCerebral cortex (New York, N.Y. : 1991)2020
Altered Sensitivity to Motion of Area MT Neurons Following Long-Term V1 Lesions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pathway-dependent brain stimulation responses indicate motion processing integrity after stroke.Brain : a journal of neurology · 2025Trial
- From error to evidence: blindsight in the making†.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Movements induced by optic flow in relation to HINE.Scientific reports · 2025Article
- What V1 Damage Can Teach Us About Visual Perception and Learning.Annual review of vision science · 2025Review
- Exogenous Spatial Attention Helps Overcome Spatial Specificity of Visual Learning in the Blind Field After V1 Damage.Journal of cognitive enhancement : towards the integration of theory and practice · 2025Article
- Impact of Deprivation and Preferential Usage on Functional Connectivity Between Early Visual Cortex and Category-Selective Visual Regions.Human brain mapping · 2024Article
- Article
- Remodeling of lateral geniculate nucleus projections to extrastriate area MT following long-term lesions of striate cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The nature of blindsight: implications for current theories of consciousness.Neuroscience of consciousness · 2022Review
- Neurochemical changes in the primate lateral geniculate nucleus following lesions of striate cortex in infancy and adulthood: implications for residual vision and blindsight.Brain structure & function · 2021Article
- Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients.Nature communications · 2021Article
- Visual response characteristics of neurons in the second visual area of marmosets.Neural regeneration research · 2021Article
- Rehabilitation of cortically induced visual field loss.Current opinion in neurology · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Primates with primary visual cortex (V1) damage often retain residual motion sensitivity, which is hypothesized to be mediated by middle temporal area (MT). MT neurons continue to respond to stimuli shortly after V1 lesions; however, experimental and clinical studies of lesion-induced plasticity have shown that lesion effects can take several months to stabilize. It is unknown what physiological changes occur in MT and whether neural responses persist long after V1 damage. We recorded neuronal responses in MT to moving dot patterns in adult marmoset monkeys 6-12 months after unilateral V1 lesions. In contrast to results obtained shortly after V1 lesions, we found that fewer MT neurons were direction selective, including neurons expected to still receive projections from remaining parts of V1. The firing rates of most cells increased with increases in motion strength, regardless of stimulus direction. Furthermore, firing rates were higher and more variable than in control MT cells. To test whether these observations could be mechanistically explained by underlying changes in neural circuitry, we created a network model of MT. We found that a local imbalance of inhibition and excitation explained the observed firing rate changes. These results provide the first insights into functional implications of long-term plasticity in MT following V1 lesions.
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