Evidence map›Paper›PMID 31211163›Full record

ArticleOpen forum infectious diseases2019

High Yield of Active Tuberculosis Case Finding Among HIV-Infected Patients Using Xpert MTB/RIF Testing.

Russell R Kempker, Nikoloz Chkhartishvili, Inga Kinkladze, Marcos C Schechter, Kristin Harrington, Nino Rukhadze, Lela Dzigua, Tengiz Tserstvadze, Carlos Del Rio, Henry M Blumberg and 1 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. A systematic review of the number needed to screen for active TB among people living with HIV.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Performance of Xpert MTB/RIF for Diagnosis of Tuberculosis in HIV-Infected People in China: A Retrospective, Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Russell R KempkerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Nikoloz ChkhartishviliInfectious Diseases, AIDS, and Clinical Immunology Research Center, Tbilisi, Georgia.
Inga KinkladzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Marcos C SchechterDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Kristin HarringtonEmory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-9306-4980
Nino RukhadzeInfectious Diseases, AIDS, and Clinical Immunology Research Center, Tbilisi, Georgia.
Lela DziguaInfectious Diseases, AIDS, and Clinical Immunology Research Center, Tbilisi, Georgia.
Tengiz TserstvadzeInfectious Diseases, AIDS, and Clinical Immunology Research Center, Tbilisi, Georgia.
Carlos Del RioDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Henry M BlumbergDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Nestani TukvadzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
Intra Cavitary Pharmacokinetics and Drug Resistance in Pulmonary TuberculosisK23AI103044 · NIAID · EMORY UNIVERSITY · PI KEMPKER, RUSSELL RYAN · 2013 to 2017
$910k
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR TuberculosisR21AI122001 · NIAID · EMORY UNIVERSITY · PI KEMPKER, RUSSELL RYAN · 2016 to 2017
$369k
FIC NIH HHS D43 TW007124NCATS NIH HHS UL1 TR000454NIAID NIH HHS K23 AI103044NIAID NIH HHS P30 AI050409NIAID NIH HHS R21 AI122001NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

objectiveConduct an active case finding study in Tbilisi, Georgia, for pulmonary tuberculosis (TB) among people living with HIV (PLWH).

methodsNewly diagnosed HIV patients were assessed for symptoms and asked to submit sputum samples for smear microscopy, culture, and molecular diagnostic testing (Xpert MTB/RIF).

resultsAmong 276 PLWH, 131 agreed to participate and 103 submitted sputum samples. Most participants were male (70%) and mean age of 43 years. There were high rates of a positive hepatitis C virus (HCV) antibody test (46%) and the median CD4 count was 122 cells/mm

conclusionOur findings highlight the high prevalence of TB among newly diagnosed HIV-infected patients in an area with high rates of drug-resistant TB and the utility of an active case finding strategy for TB diagnosis.

Indexed as

Case findingGeorgiaTbilisiTB symptoms

Identifiers

PMID31211163
PMCPMC6559269

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.