Evidence map›Paper›PMID 31210961›Full record

ArticlePilot and feasibility studies2019

Rapid Analgesia for Prehospital hip Disruption (RAPID): findings from a randomised feasibility study.

Jenna K Jones, Bridie A Evans, Greg Fegan, Simon Ford, Katy Guy, Sian Jones, Leigh Keen, Ashrafunnesa Khanom, Mirella Longo, Ian Pallister and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pilot and feasibility studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Peripheral nerve blocks for hip fractures in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Jenna K Jones1Swansea University Medical School, Swansea, UK.ORCID 0000-0002-1280-4941
Bridie A Evans1Swansea University Medical School, Swansea, UK.
Greg Fegan1Swansea University Medical School, Swansea, UK.
Simon FordSwansea Bay University Health Board, Swansea, UK.
Katy GuySwansea Bay University Health Board, Swansea, UK.
Sian Jones3Patient and public representative, c/o Swansea University Medical School, Swansea, UK.
Leigh Keen4Welsh Ambulance Services NHS Trust, Saint Asaph, UK.
Ashrafunnesa Khanom1Swansea University Medical School, Swansea, UK.
Mirella LongoCardiff School of Medicine, Cardiff, UK.
Ian Pallister1Swansea University Medical School, Swansea, UK.
Nigel Rees4Welsh Ambulance Services NHS Trust, Saint Asaph, UK.
Ian T Russell1Swansea University Medical School, Swansea, UK.
Anne C Seagrove1Swansea University Medical School, Swansea, UK.
Alan Watkins1Swansea University Medical School, Swansea, UK.
Helen A Snooks1Swansea University Medical School, Swansea, UK.
Swansea University · GBSwansea Bay University Health Board · GBWelsh Ambulance Services NHS Trust · GBCardiff University · GB

Funding

Marie Curie MCCC-FCO-11-C
6 · The paper itself

Abstract

backgroundIn managing hip fracture, effective pain relief before admission to hospital is difficult without risking side effects. Although emergency departments routinely use fascia iliaca compartment block (FICB), there has been little evaluation of its use by paramedics before hospital admission. We aimed to assess whether a multi-centre randomised trial to evaluate FICB was feasible.

methodsVolunteer paramedics used scratchcards to allocate patients with hip fracture at random between FICB and pain relief as usual. Primary outcomes were mortality and quality of life. We also measured adverse events, costs, final diagnosis, length of stay in hospital, pain scores and quality of care and collected qualitative data about acceptability to patients in interviews, and paramedics in focus groups. We pre-specified criteria for deciding whether to progress to a fully powered trial based on the recruitment of paramedics and patients, delivery of FICB, retrieval of outcome data, safety, acceptability, and diagnostic accuracy of hip fracture.

resultsWe effectively met all progression criteria: we recruited 19 paramedics who randomly allocated 71 patients between trial arms between 28 June 2016 and 31 July 2017; 57 (31 experimental arm, 26 usual care arm, 80% overall) retrospectively consented to follow-up. Just over half (17/31) of experimental participants received FICB; all others had contraindications, including nine taking anticoagulants. Four of the 31 participants assigned FICB and six of the 26 assigned usual care died within 6 months of hospital admission. Serious adverse events were also similar: 3/35 experimental versus 4/36 in usual care. Paramedics' recognition of hip fracture had sensitivity of 49/64 (77%) with a positive predictive value of 46/57 (81%). We received quality of life questionnaires for 30 of 49 patients (61%) at 1 month and 12 of 17 (71%) at 6 months. Patient satisfaction was similar: experimental mean 3.4 (

conclusionsRAPID met all progression criteria within reasonable limits. As equipoise remains, we plan to undertake a fully powered multi-centre trial to test clinical and cost effectiveness of paramedic-administered FICB at the scene of hip fracture.

trial registrationISRCTN 60065373 sought 5 November 2015.

Indexed as

AnalgesiaFascia iliaca compartment blockFeasibility studyFractured neck of femurHip fractureParamedicPre-hospitalRandomised trial

Identifiers

PMID31210961
PMCPMC6560881
OpenAlexW2949951976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.