Observational studyUnited European gastroenterology journal2019
The impact of technical and clinical factors on fecal microbiota transfer outcomes for the treatment of recurrent
Observational study in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02681068 (MicroTrans - A Multicenter Registry of Fecal Microbiota Transplantation), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MicroTrans - A Multicenter Registry of Fecal Microbiota Transplantation
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- Evaluation of a phage-inclusive multimodal strategy for recurrent urinary tract infections.BMC microbiology · 2026Article
- Ecological resilience in ulcerative colitis: microbial dynamics of donor and resident species in a longitudinal fecal microbiota transplantation study.ISME communications · 2025Article
- Factors for Treatment Failure After Fecal Microbiota Transplantation inMicroorganisms · 2024Article
- Current Status of Microneedle Array Technology for Therapeutic Delivery: From Bench to Clinic.Molecular biotechnology · 2024Review
- Drivers and determinants of strain dynamics following fecal microbiota transplantation.Nature medicine · 2022Article
- Adverse events of intestinal microbiota transplantation in randomized controlled trials: a systematic review and meta-analysis.Gut pathogens · 2022Review
- Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation.Gastroenterology · 2021Article
- A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group.United European gastroenterology journal · 2021Article
- Systematic review with meta-analysis: encapsulated faecal microbiota transplantation - evidence for clinical efficacy.Therapeutic advances in gastroenterology · 2021Article
- Faecal microbiota transplantation for recurrentEClinicalMedicine · 2020Article
- Faecal microbiota transplantation forUnited European gastroenterology journal · 2020Observational
- Fecal Microbiota Transfer.Deutsches Arzteblatt international · 2020Review
- Review
- Adverse events in fecal microbiota transplantation: a systematic review and meta-analysis.Annals of gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 16 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Fecal microbiota transfer (FMT) is highly effective in the treatment and prevention of recurrent Methods: Information was extracted from the MicroTrans Registry (NCT02681068), a retrospective observational multicenter study, collecting data from patients undergoing FMT for recurrent or refractory CDI in Germany. We performed binary logistic regression with the following covariates: age, gender, ribotype 027, Eastern Co-operative Oncology Group score, immunosuppression, preparation for FMT by use of proton pump inhibitor, antimotility agents and bowel lavage, previous recurrences, severity of CDI, antibiotic induction treatment, fresh or frozen FMT preparation, and route of application. Results: Treatment response was achieved in 191/240 evaluable cases (79.6%) at day 30 (D30) post FMT and 78.1% at day 90 (D90) post FMT. Assessment of clinical predictors for FMT failure by forward and confirmatory backward-stepwise regression analysis yielded higher age as an independent predictor of FMT failure ( Conclusion: FMT in Germany is associated with high cure rates at D30 and D90. No specific pre-treatment, preparation or application strategy had an impact on FMT success. Only higher age was identified as an independent risk factor for treatment failure. Based on these and external findings, future studies should focus on the assessment of microbiota and microbiota-associated metabolites as factors determining FMT success.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.