Evidence map›Paper›PMID 31210946›Full record

ArticleUnited European gastroenterology journal2019

Incidental findings in pancreas screening programs for high-risk individuals: Results from three European expert centers.

Isaura S Ibrahim, Catharina Brückner, Alfredo Carrato, Julie Earl, Akin Inderson, Wouter H de Vos Tot Nederveen Cappel, Ioannis Mintziras, Elvira Matthäi, Jens Figiel, Martin Wasser and 5 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Isaura S IbrahimDepartment of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-6457-1502
Catharina BrücknerDepartment of Visceral-, Thoracic- and Vascular Surgery, University Hospital Marburg, Marburg, Germany.
Alfredo CarratoDepartment of Medical Oncology, Ramon y Cajal University Hospital, Madrid, Spain.
Julie EarlDepartment of Medical Oncology, Ramon y Cajal University Hospital, Madrid, Spain.
Akin IndersonDepartment of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Wouter H de Vos Tot Nederveen CappelDepartment of Gastroenterology & Hepatology, Isala Clinics, Zwolle, the Netherlands.
Ioannis MintzirasDepartment of Visceral-, Thoracic- and Vascular Surgery, University Hospital Marburg, Marburg, Germany.
Elvira MatthäiDepartment of Visceral-, Thoracic- and Vascular Surgery, University Hospital Marburg, Marburg, Germany.
Jens FigielDepartment of Radiology, University Hospital Marburg, Marburg, Germany.
Martin WasserDepartment of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Hans MoreauDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Bert BonsingDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Emily P SlaterDepartment of Visceral-, Thoracic- and Vascular Surgery, University Hospital Marburg, Marburg, Germany.
Detlef K BartschDepartment of Visceral-, Thoracic- and Vascular Surgery, University Hospital Marburg, Marburg, Germany.
Hans Fa VasenDepartment of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Leiden University Medical Center · NLPhilipps University of Marburg · DEInstituto Cajal · ESIsala · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Widespread abdominal imaging has led to a substantial increase in the detection of incidentalomas. Currently, an increasing number of centers offer surveillance of the pancreas to individuals at high risk (IARs) of pancreatic ductal adenocarcinoma (PDAC). Objective: The aims of this study were to evaluate the frequency and type of incidental findings in a magnetic resonance imaging (MRI)-based surveillance program for IARs for PDAC, and to discuss the benefit of detecting these lesions. Methods: The outcome of MRI screening was reviewed in 568 individuals from three long-term pancreas surveillance programs conducted at three large European expert centers. All MRIs were studied in detail for the presence of incidental lesions. Results: The most common lesions were liver cysts, renal cysts and liver hemangioma, which together comprised 75% of all lesions. Only five (0.9%) patients underwent surgery for a benign lesion. Cancer was detected in 11 patients (1.9%); early detection of tumors was beneficial in at least five cases. Conclusion: The present study demonstrates that extrapancreatic incidentaloma is a common finding in IARs for PDAC, but rarely requires additional treatment.

Indexed as

Incidental FindingsMagnetic Resonance ImagingCarcinoma, Pancreatic DuctalCyclin-Dependent Kinase Inhibitor p16Early Detection of CancerFemaleGenetic Predisposition to DiseaseHumansMaleMass ScreeningMiddle AgedMutationPancreatic NeoplasmsRetrospective StudiesRisk FactorsCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16genetic predispositionHigh-risk individualsincidental findingsincidentalomaPDACscreeningsurveillance

Identifiers

PMID31210946
PMCPMC6545710
OpenAlexW2930047957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.