Evidence map›Paper›PMID 31210787›Full record

ArticleGut pathogens2019

Proton pump inhibitors and 180-day mortality in the elderly after

Evan Stuart Bradley, Emily Howe, Xun Wu, John P Haran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Evan Stuart BradleyDepartment of Emergency Medicine, University of Massachusetts Medical School and Umass Memorial Medical Center, 55 North Lake Avenue, Worcester, MA 01605 USA.ORCID 0000-0001-7704-6371
Emily Howe2University of Massachusetts Medical School, 55 North Lake Avenue, Worcester, MA 01605 USA.
Xun Wu2University of Massachusetts Medical School, 55 North Lake Avenue, Worcester, MA 01605 USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Medical School and Umass Memorial Medical Center, 55 North Lake Avenue, Worcester, MA 01605 USA.
UMass Memorial Health Care · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a reported association between proton pump inhibitor (PPI) exposure and increased risk of

resultsOf the 874 elderly adults treated for CDI, 180-day all-cause mortality was 12.4%. Exposure to a PPI was associated with a 55% reduced risk of mortality (adjusted hazard ratio (aHR) 0.45; 95% confidence interval (CI) 0.28-0.72). In our Cox model, increasing age (aHR 1.45; 95% CI 1.14-1.84), those with severe CDI infections (aHR 1.87; 95% CI 1.22-2.88), and those with hospital acquired CDI (aHR 3.01; 95% CI 1.81-4.99) also had increased 180 day mortality risk. There were similar associations noted with both 90 day and 1-year mortality.

conclusionUse of PPIs during CDI treatment in elderly patients is associated with decreased 180-day mortality. Although use of PPIs has been associated with an increased risk of CDI, it appears to be protective against mortality when used during the treatment phase.

Indexed as

Clostridium difficileEnteric pathogensInfectious diseaseMedication safetyProton pump inhibitors

Identifiers

PMID31210787
PMCPMC6563367
OpenAlexW2953351373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.