Evidence map›Paper›PMID 31210637›Full record

ArticleeLife2019

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.

Jean Paul Armache, Nathan Gamarra, Stephanie L Johnson, John D Leonard, Shenping Wu, Geeta J Narlikar, Yifan Cheng

Open access · greenAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 61 citations in OpenAlex.

  1. Tuning epigenetics to enhance cancer virotherapy.Acta pharmaceutica Sinica. B · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Cryo-EM structure of ALC1 in an open conformation bound to a PARylated nucleosome.Acta crystallographica. Section D, Structural biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. How does CHD4 slide nucleosomes?Biochemical Society transactions · 2024
    Review
  12. Article
  13. Cryo-EM structure and functional analysis of the chromatin remodeler RSF.Acta crystallographica. Section F, Structural biology communications · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jean Paul Armache *Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-9195-2282
Nathan Gamarra *Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-2430-8662
Stephanie L JohnsonDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
John D LeonardDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Shenping WuHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.
Geeta J NarlikarDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-1920-0147
Yifan ChengDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-9535-0369
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Measuring the lifetime and mechanical stability of phase-separated heterochromatin domainsR35GM127020 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GEETA J NARLIKAR · 2018 to 2026
$7.3M
Mechanistic Analysis of Chromatin RemodelingR01GM073767 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NARLIKAR, GEETA J · 2005 to 2018
$4.7M
Mechanism of gate-opening in the 20S proteasome induced by the proteasomal ATPaseR01GM082893 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2008 to 2017
$2.8M
Mechanistic dissection of HP1 mediated heterochromatinR01GM108455 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NARLIKAR, GEETA J · 2014 to 2017
$1.7M
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
NIGMS NIH HHS R01 GM073767NIGMS NIH HHS R01 GM082893NIGMS NIH HHS R01 GM108455NIGMS NIH HHS R35 GM127020NIH HHS 1S10OD020054NIH HHS GM073767NIH HHS GM108455NIH HHS R01GM082893NIH HHS S10 OD020054University of California, San Francisco Program for Breakthrough Biomedical Research
6 · The paper itself

Abstract

The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis remains unknown. Here we present cryo-EM structures of SNF2h-nucleosome complexes with ADP-BeF

Indexed as

Adenosine TriphosphatasesAllosteric RegulationChromosomal Proteins, Non-HistoneCryoelectron MicroscopyHistonesHumansNucleosomesProtein ConformationProtein MultimerizationAdenosine TriphosphatasesChromosomal Proteins, Non-HistoneHistonesNucleosomesSMARCA5 protein, humanATPasechromatin remodelingchromosomesCryoEMgene expressionhumanISWImolecular biophysicsnucleosomesmFRETstructural biology

Identifiers

PMID31210637
PMCPMC6611695
OpenAlexW2949386465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.