Evidence map›Paper›PMID 31210561›Full record

ArticleHuman vaccines & immunotherapeutics2020

Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E.

Dan-Yang Shi, Fu-Jia Liu, Yun-Yun Mao, Rong-Tian Cui, Jian-Sheng Lu, Yun-Zhou Yu, Xiao-Jie Dong, Zhi-Xin Yang, Zhi-Wei Sun, Xiao-Bin Pang

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Botulinum neurotoxin: from molecular pathogenesis to emerging countermeasures.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Development and evaluation of a tetravalent botulinum vaccine.Human vaccines & immunotherapeutics · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dan-Yang ShiDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Fu-Jia LiuDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Yun-Yun MaoDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Rong-Tian CuiDepartment of Drug Registration, Jiangsu T-mab BioPharma Co., Ltd, Taizhou, China.
Jian-Sheng LuDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Yun-Zhou YuDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Xiao-Jie DongDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Zhi-Xin YangDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Zhi-Wei SunDepartment of Protein Engineering, Beijing Institute of Biotechnology, Beijing, China.
Xiao-Bin PangPharmaceutical College, Henan University, Kaifeng, China.
Henan University · CNJiangsu T-mab BioPharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin serotype E (rEHc) was expressed in

Indexed as

AnimalsAntibodies, BacterialAntitoxinsBacterial VaccinesBotulinum ToxinsBotulismFemaleHorsesImmunogenicity, VaccineMiceMice, Inbred BALB CVaccinationVaccines, SubunitVaccines, SyntheticAntibodies, BacterialAntitoxinsBacterial VaccinesBotulinum Toxinsbotulinum toxin type EVaccines, SubunitVaccines, SyntheticantitoxinBotulinum neurotoxinHc domainsubunit vaccine

Identifiers

PMID31210561
PMCPMC7012155
OpenAlexW2953185138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.