Evidence map›Paper›PMID 31210010›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Visible-Light-Promoted Iron-Catalyzed C(sp

Xiao-Jing Wei, Irini Abdiaj, Carlo Sambiagio, Chenfei Li, Eli Zysman-Colman, Jesús Alcázar, Timothy Noël

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Cooperative Photoredox Catalysis Under Confinement.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. PhotoinducedJACS Au · 2023
    Article
  7. Iron Photoredox Catalysis-Past, Present, and Future.Journal of the American Chemical Society · 2023
    Review
  8. Organometallic catalysis under visible light activation: benefits and preliminary rationales.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Flow Photochemistry as a Tool in Organic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Review
  16. Article
  17. Optimization of a Decatungstate-Catalyzed C(spOrganic process research & development · 2020
    Article
  18. Article
  19. Article
  20. Visible-Light-Promoted Iron-Catalyzed C(spAngewandte Chemie (International ed. in English) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao-Jing WeiDepartment of Chemical Engineering and Chemistry, Micro Flow Chemistry and Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612, AZ, Eindhoven, The Netherlands.
Irini AbdiajDiscovery Sciences, Janssen Research and Development, Jannsen-Cilag, S.A., Jarama 75A, 45007, Toledo, Spain.
Carlo SambiagioDepartment of Chemical Engineering and Chemistry, Micro Flow Chemistry and Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612, AZ, Eindhoven, The Netherlands.ORCID 0000-0001-8536-103X
Chenfei LiOrganic Semiconductor Center, EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, UK.
Eli Zysman-ColmanOrganic Semiconductor Center, EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, UK.
Jesús AlcázarDiscovery Sciences, Janssen Research and Development, Jannsen-Cilag, S.A., Jarama 75A, 45007, Toledo, Spain.
Timothy NoëlDepartment of Chemical Engineering and Chemistry, Micro Flow Chemistry and Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612, AZ, Eindhoven, The Netherlands.ORCID 0000-0002-3107-6927

Funding

Photo4Future 14150
6 · The paper itself

Abstract

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes' residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.

Indexed as

cross-couplingflow chemistryiron catalysisKumada couplingphotocatalysis

Identifiers

PMID31210010
PMCPMC6771604

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.