Evidence map›Paper›PMID 31209938›Full record

ArticleMagnetic resonance in medicine2019

Prospective acceleration of parallel RF transmission-based 3D chemical exchange saturation transfer imaging with compressed sensing.

Hye-Young Heo, Xiang Xu, Shanshan Jiang, Yansong Zhao, Jochen Keupp, Kristin J Redmond, John Laterra, Peter C M van Zijl, Jinyuan Zhou

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  3. Article
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  6. Review
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  14. Only-train-once MR fingerprinting for BMagnetic resonance in medicine · 2023
    Article
  15. Article
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hye-Young HeoDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-7297-2015
Xiang XuDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Shanshan JiangDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Yansong ZhaoPhilips Healthcare, Cleveland, Ohio.
Jochen KeuppPhilips Research, Hamburg, Germany.
Kristin J RedmondDepartment of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, Maryland.
John LaterraF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland.
Peter C M van ZijlDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Jinyuan ZhouDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland.

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI PEKAR, JAMES J. · 2012 to 2020
$13.1M
Novel Approaches for CEST Labeling, Detection, Quantification and TranslationR01EB015032 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2011 to 2019
$3.9M
Academic-Industrial Partnership to Develop Clinical Brain Cancer ImagingR01CA166171 · NCI · JOHNS HOPKINS UNIVERSITY · PI VAN ZIJL, PETER CM, ZHOU, JINYUAN · 2013 to 2017
$2.4M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3TR01CA228188 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2019 to 2022
$1.6M
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisR00EB026312 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI XU, XIANG · 2020 to 2022
$747k
Highly Accelerated Chemical Exchange Saturation Transfer MRI Using Compressed SensingR21CA227783 · NCI · JOHNS HOPKINS UNIVERSITY · PI HEO, HYE YOUNG · 2018 to 2019
$385k
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisK99EB026312 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, XIANG · 2018 to 2020
$242k
NCI NIH HHS R01 CA166171NCI NIH HHS R01 CA228188NCI NIH HHS R21 CA227783NIBIB NIH HHS K99 EB026312NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R00 EB026312NIBIB NIH HHS R01 EB015032
6 · The paper itself

Abstract

purposeTo develop prospectively accelerated 3D CEST imaging using compressed sensing (CS), combined with a saturation scheme based on time-interleaved parallel transmission.

methodsA variable density pseudo-random sampling pattern with a centric elliptical k-space ordering was used for CS acceleration in 3D. Retrospective CS studies were performed with CEST phantoms to test the reconstruction scheme. Prospectively CS-accelerated 3D-CEST images were acquired in 10 healthy volunteers and 6 brain tumor patients with an acceleration factor (R

resultsThe APTw signals obtained from the CS with acceleration factor of 4 were well-preserved as compared with the reference image (SENSE R = 2) both in retrospective phantom and prospective healthy volunteer studies. In the patient study, the APTw signals were significantly higher in the tumor region (gadolinium [Gd]-enhancing tumor core) than in the normal tissue (p < .001). There was no significant APTw difference between the CS-accelerated images and the reference image. The scan time of CS-accelerated 3D APTw imaging was dramatically reduced to 2:10 minutes (in-plane spatial resolution of 1.8

conclusionCompressed sensing acceleration was successfully extended to 3D-CEST imaging without compromising CEST image quality and quantification. The CS-based CEST imaging can easily be integrated into clinical protocols and would be beneficial for a wide range of applications.

Indexed as

AdultBrain NeoplasmsContrast MediaData CompressionFemaleGliomaHealthy VolunteersHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMalePhantoms, ImagingProspective StudiesRetrospective StudiesContrast MediaAPTbrain tumorCESTcompressed sensingparallel RF transmission

Identifiers

PMID31209938
PMCPMC6660350

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.