ArticleInternational journal of cancer2020
DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility.
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Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Single nucleotide polymorphisms: impact on susceptibility to chemotherapy in patients with colorectal cancer.Future science OA · 2024Article
- Integrative nomogram model based on anoikis-related genes enhances prognostic evaluation in colorectal cancer.Heliyon · 2024Article
- Identification of a prognostic DNA repair gene signature in esophageal cancer.Journal of gastrointestinal oncology · 2024Article
- NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer.Journal of clinical medicine · 2024Article
- Gene-Environment Analyses in a UK Biobank Skin Cancer Cohort Identifies Important SNPs in DNA Repair Genes That May Help Prognosticate Disease Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Identification of a RAD51B enhancer variant for susceptibility and progression to glioma.Cancer cell international · 2023Article
- Integrated bioinformatics and wet-lab analysis revealed cell adhesion prominent genes CDC42, TAGLN and GSN as prognostic biomarkers in colonic-polyp lesions.Scientific reports · 2023Article
- The role of DNA mismatch repair in immunotherapy of human cancer.International journal of biological sciences · 2022Review
- Patterns and grades of presentation of colon cancer in Northern Saudi Arabia.Przeglad gastroenterologiczny · 2021Article
- Apoptosis Induced by Ziziphora tenuior Essential Oil in Human Colorectal Cancer Cells.BioMed research international · 2021Article
- Characteristics of Pan-Cancer Patients With Ultrahigh Tumor Mutation Burden.Frontiers in oncology · 2021Article
- DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers.International journal of molecular sciences · 2020Review
- Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients.International journal of molecular sciences · 2020Review
- Identification of Hub Genes Associated With Hepatocellular Carcinoma Using Robust Rank Aggregation Combined With Weighted Gene Co-expression Network Analysis.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
41 authors at 20 institutions in 8 countries.
Barbara PardiniItalian Institute for Genomic Medicine (IIGM), Turin, Italy.ORCID 0000-0001-9571-4257
Alda CorradoDepartment of Biology, University of Pisa, Pisa, Italy.
Elisa PaolicchiDepartment of Biology, University of Pisa, Pisa, Italy.
Giovanni CugliariItalian Institute for Genomic Medicine (IIGM), Turin, Italy.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
Stephane BezieauService de Génétique Médicale, Centre Hospitalier Universitaire (CHU), Nantes, France.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bette J CaanKaiser Permanente Medical Care Program of Northern California, Oakland, CA.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Graham CaseyPublic Health Sciences, University of Virginia, Charlottesville, VA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michelle CotterchioPrevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.
Manish GalaDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA.
Steven J GallingerDepartment of Surgery, Mount Sinai Hospital, Toronto, ON, Canada.
Robert W HaileStanford University School of Medicine, Stanford, CA.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
John L HopperMelbourne School of Population Health, The University of Melbourne, Melbourne, VIC, Australia.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Jeroen HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Mark A JenkinsMelbourne School of Population Health, The University of Melbourne, Melbourne, VIC, Australia.
Loic Le MarchandEpidemiology Program, Research Cancer Center of Hawaii, University of Hawaii, Honolulu, HI.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, AZ.
Hongmei NanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Shuji OginoProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.ORCID 0000-0002-1655-6543
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Ludmila VodickovaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Veronika VymetalkovaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Pavel VodickaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Federica GemignaniDepartment of Biology, University of Pisa, Pisa, Italy.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Alessio NaccaratiItalian Institute for Genomic Medicine (IIGM), Turin, Italy.
Stefano LandiDepartment of Biology, University of Pisa, Pisa, Italy.
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZACzech Academy of Sciences · CZUniversity of Pisa · ITGerman Cancer Research Center · DEItalian institute for Genomic Medicine · ITMassachusetts General Hospital · USThe University of Melbourne · AUAmerican Cancer Society · USBroad Institute · USCancer Care Ontario · CACentre Hospitalier Universitaire de Nantes · FRKaiser Permanente · USMayo Clinic in Arizona · USMount Sinai Hospital · CANational Institutes of Health · USNew York University · USRichard M. Fairbanks Foundation · USStanford University · USUniversity of Hawaiʻi at Mānoa · USUniversity of Pittsburgh Medical Center · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2MPLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MUSC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MVALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
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Abstract
Interindividual differences in DNA repair systems may play a role in modulating the individual risk of developing colorectal cancer. To better ascertain the role of DNA repair gene polymorphisms on colon and rectal cancer risk individually, we evaluated 15,419 single nucleotide polymorphisms (SNPs) within 185 DNA repair genes using GWAS data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), which included 8,178 colon cancer, 2,936 rectum cancer cases and 14,659 controls. Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10
Indexed as
Genetic Predisposition to DiseaseAdultAgedBiological Variation, PopulationCarcinogenesisCase-Control StudiesColonColonic NeoplasmsDNA-Binding ProteinsDNA Modification MethylasesDNA RepairDNA Repair EnzymesFemaleHumansMaleMiddle AgedDNA-Binding ProteinsDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanMLH1 protein, humanMutL Protein Homolog 1RAD51B protein, humanTumor Suppressor Proteinscancer susceptibilitycolon cancerDNA repairgenome-wide association studiesrectal cancersingle nucleotide polymorphisms
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