Evidence map›Paper›PMID 31209863›Full record

ArticleBiotechnology and bioengineering2019

Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery.

Pin-Kuang Lai, Daniel T Tresnak, Benjamin J Hackel

Open access · greenAbstract read
In one paragraph

Article in Biotechnology and bioengineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Proline-Rich Antimicrobial Peptides from Invertebrates.Molecules (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Sequence-function mapping of proline-rich antimicrobial peptides.bioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Charting the sequence-activity landscape of peptide inhibitors of translation termination.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pin-Kuang LaiDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-2894-3900
Daniel T TresnakDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota.
Benjamin J HackelDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-3561-9463
University of Minnesota · US

Funding

Engineering Antimicrobial Polypeptides against Pathogenic BacteriaR01GM121777 · NIGMS · UNIVERSITY OF MINNESOTA · PI HACKEL, BENJAMIN · 2017 to 2020
$1.1M
NIGMS NIH HHS R01 GM121777
6 · The paper itself

Abstract

Proline-rich antimicrobial peptides (PrAMPs) kill bacteria via a nonlytic mechanism in which they permeate through the outer membrane, utilize protein-mediated transport across the inner membrane, and target the ribosome to inhibit protein synthesis. We previously reported that substitutions of oncocin (

Indexed as

Amino Acid SubstitutionAnti-Bacterial AgentsAntimicrobial Cationic PeptidesMutation, MissenseEscherichia coliSalmonella typhimuriumAnti-Bacterial AgentsAntimicrobial Cationic Peptidesapidaecin-1bbactenecinproline-rich antimicrobial peptidespyrrhocoricinSbmA receptor

Identifiers

PMID31209863
PMCPMC6726534
OpenAlexW2952812009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.