Evidence map›Paper›PMID 31209858›Full record

ArticleClinical pharmacology and therapeutics2019

Racial/Ethnic-Specific Differences in the Effects of Inhaled Corticosteroid Use on Bronchodilator Response in Patients With Asthma.

Lesly-Anne Samedy-Bates, Sam S Oh, Thomas J Nuckton, Jennifer R Elhawary, Marquitta White, Tyronda Elliot, Andy M Zeiger, Celeste Eng, Sandra Salazar, Michael A LeNoir and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pharmacology and therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Neighborhood Deprivation and Crime on Asthma Exacerbations and Utilization in Mild Adult Asthma.The journal of allergy and clinical immunology. In practice · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Genetic Determinants of Poor Response to Treatment in Severe Asthma.International journal of molecular sciences · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 3 countries.

Lesly-Anne Samedy-BatesDepartment of Medicine, University of California, San Francisco, California, USA.
Sam S OhDepartment of Medicine, University of California, San Francisco, California, USA.
Thomas J NucktonDepartment of Medicine, University of California, San Francisco, California, USA.
Jennifer R ElhawaryDepartment of Medicine, University of California, San Francisco, California, USA.
Marquitta WhiteDepartment of Medicine, University of California, San Francisco, California, USA.
Tyronda ElliotDepartment of Medicine, University of California, San Francisco, California, USA.
Andy M ZeigerDepartment of Medicine, University of California, San Francisco, California, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, California, USA.
Sandra SalazarDepartment of Medicine, University of California, San Francisco, California, USA.
Michael A LeNoirBay Area Pediatrics, Oakland, California, USA.
Kelley MeadeChildren's Hospital and Research Center Oakland, Oakland, California, USA.
Harold J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Denise SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, New York, USA.
Emerita Brigino-BuenaventuraDepartment of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, California, USA.
William Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, Puerto Rico, USA.
Kirsten Bibbins-DomingoDepartment of Medicine, University of California, San Francisco, California, USA.
Rajesh KumarThe Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Shannon ThyneDepartment of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
Luisa N BorrellDepartment of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, New York, USA.
José R Rodriguez-SantanaCentro de Neumologia Pediatrica, Caguas, Puerto Rico, USA.
Maria Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, California, USA.
University of California, San Francisco · USCentro de Neumologia Pediatrica · PRCity University of New York · USInstituto de Salud Carlos III · ESJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USLurie Children's Hospital · USTexas Children's Hospital · USUniversity of California, Los Angeles · USVA Caribbean Healthcare System · PR

Funding

The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
National Longitudinal Evaluation of the RISE ProgramR01GM075316 · NIGMS · CALIFORNIA STATE UNIVERSITY SAN MARCOS · PI ESTRADA, MICA BETH, SCHULTZ, PAUL WESLEY · 2005 to 2016
$4.9M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
Genes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8M
Genetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1M
Integrative Analyses to Uncover Biological Mechanisms Mediating Gene Associations with Asthma Drug Response Among Minority ChildrenR01HL141992 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BURCHARD, ESTEBAN GONZALEZ, HIMES, BLANCA E · 2018 to 2019
$855k
Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse ChildrenR21ES024844 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, GAUDERMAN, WILLIAM JAMES · 2015 to 2017
$509k
Integrative Genetics and Genomics of Obese-Asthma in Minority ChildrenK01HL140218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WHITE, MARQUITTA · 2018 to 2020
$457k
NHLBI NIH HHS K01 HL140218NHLBI NIH HHS L40 HL143533NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141992NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS R01 GM075316NIGMS NIH HHS RL5 GM118984NIGMS NIH HHS T32 GM007546NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

American Thoracic Society guidelines recommend inhaled corticosteroid (ICS) therapy, plus a short-acting bronchodilator, in patients with persistent asthma. However, few prior studies have examined the efficacy of this combination in children of all racial/ethnic groups. We evaluated the association between ICS use and bronchodilator response (BDR) in three pediatric populations with persistent asthma (656 African American, 916 Puerto Rican, and 398 Mexican American children). The association was assessed using multivariable quantile regression. After adjusting for baseline forced expiratory volume in one second and use of controller medications, ICS use was significantly associated with increased BDR only among Mexican Americans (1.56%, P = 0.028) but not African Americans (0.49%, P = 0.426) or Puerto Ricans (0.16%, P = 0.813). Our results demonstrate that ICS augmentation is disproportionate across racial/ethnic groups, where improved BDR is observed in Mexican Americans only. This study highlights the complexities of treating asthma in children, and reinforces the importance of investigating the influence of race/ethnicity on pharmacological response.

Indexed as

Administration, InhalationAdolescentAdrenal Cortex HormonesAsthmaBlack or African AmericanBronchodilator AgentsChildFemaleForced Expiratory VolumeHispanic or LatinoHumansMaleMexican AmericansPuerto RicoRacial GroupsUnited StatesAdrenal Cortex HormonesBronchodilator Agents

Identifiers

PMID31209858
PMCPMC6778006
OpenAlexW2951711682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.