Evidence map›Paper›PMID 31209836›Full record

ArticleBrain imaging and behavior2020

Differential associations of engagement in physical activity and estimated cardiorespiratory fitness with brain volume in middle-aged to older adults.

David A Raichlen, Yann C Klimentidis, Pradyumna K Bharadwaj, Gene E Alexander

Open access · greenAbstract read
In one paragraph

Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Associations of sleep behaviors with white matter hyperintensity volume in middle-aged to older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  11. Hippocampal Subfield Volumes in Amateur Marathon Runners.Medicine and science in sports and exercise · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David A RaichlenSchool of Anthropology, University of Arizona, 1009 E. South Campus Dr., Tucson, AZ, 85721, USA. raichlen@email.arizona.edu.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Pradyumna K BharadwajDepartment of Psychology, University of Arizona, 1503 E. University, Tucson, AZ, 85721, USA.
Gene E AlexanderBIO5 Institute, University of Arizona, Tucson, AZ, USA. gene.alexander@arizona.edu.
University of Arizona · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
Augmenting Cognitive Training in Older Adults - The ACT GrantR01AG054077 · NIA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, MARSISKE, MICHAEL · 2016 to 2020
$6.9M
Epigenetic, Neuroimaging & Behavioral Effects of Hypertension in the Aging BrainR01AG049464 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, BARNES, CAROL A. · 2014 to 2018
$2.4M
Genetics at the Interface of Lipid and Glycemic TraitsR01HL136528 · NHLBI · UNIVERSITY OF ARIZONA · PI KLIMENTIDIS, YANN CHARLES · 2018 to 2020
$1.1M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853National Science Foundation BCS 1440867NHLBI NIH HHS R01 HL136528NIA NIH HHS AG019610NIA NIH HHS AG049464NIA NIH HHS AG054077NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG049464NIA NIH HHS R01 AG054077
6 · The paper itself

Abstract

Previous work has confirmed the benefits of aerobic exercise for brain aging, however mechanisms underlying these effects remain unclear. Two measures of exercise, time spent in moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF), may reflect different pathways linking activity to brain health. Using data from the UK Biobank, the largest sample combining neuroimaging and objectively measured MVPA available to date (n = 7148, n

Indexed as

Organ SizeAgedAged, 80 and overBrainCardiorespiratory FitnessExerciseFemaleGray MatterHumansMaleMiddle AgedExerciseGray matterHippocampusMRIVO2MAX

Identifiers

PMID31209836
PMCPMC7008962
OpenAlexW2949202259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.