Evidence map›Paper›PMID 31209835›Full record

ArticleBrain imaging and behavior2019

Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults.

Paola M Garcia-Egan, Rebecca N Preston-Campbell, Lauren E Salminen, Jodi M Heaps-Woodruff, Lila Balla, Ryan P Cabeen, David H Laidlaw, Thomas E Conturo, Robert H Paul

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Paola M Garcia-EganDepartment of Psychological Sciences, University of Missouri, St. Louis, MO, 63121, USA.
Rebecca N Preston-CampbellMissouri Institute of Mental Health, St. Louis, MO, 63134, USA.
Lauren E SalminenImaging Genetics Center, Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, CA, 90292, USA.
Jodi M Heaps-WoodruffMissouri Institute of Mental Health, St. Louis, MO, 63134, USA.
Lila BallaMissouri Institute of Mental Health, St. Louis, MO, 63134, USA.
Ryan P CabeenLaboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, LosAngeles, CA, 90033, USA.
David H LaidlawDepartment of Computer Science, Brown University, Providence, RI, 02906, USA.
Thomas E ConturoMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Robert H PaulDepartment of Psychological Sciences, University of Missouri, St. Louis, MO, 63121, USA. paulro@umsl.edu.
Missouri Institute of Mental Health · USUniversity of Missouri–St. Louis · USUniversity of Southern California · USBrown University · USMallinckrodt (United States) · US

Funding

Neuromarkers of age-related cognitive declineR01NS052470 · NINDS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI PAUL, ROBERT HARRIS · 2007 to 2011
$2.7M
TRACKING NEURONAL FIBERS IN LIVING HUMAN BRAIN BY MRIR01NS039538 · NINDS · WASHINGTON UNIVERSITY · PI CONTURO, THOMAS EDWARD · 2001 to 2005
$2.1M
DEVELOPMENTAL CHARACTERISTICS OF MRI DIFFUSION TENSOR PATHWAY CHANGES IN AUTISMR21MH090494 · NIMH · WASHINGTON UNIVERSITY · PI CONTURO, THOMAS EDWARD · 2010 to 2011
$441k
NIMH NIH HHS R21 MH090494NINDS NIH HHS R01 NS039538NINDS NIH HHS R01 NS052470NINDS NIH HHS R01 NS052470, R01 NS039538
6 · The paper itself

Abstract

Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51-78 years). Participants underwent neuroimaging with 3 Tesla MRI, and completed a behavioral test of inhibition (i.e., Go/NoGo task). Quantitative tractography derived from diffusion tensor imaging (qtDTI) was used to measure white matter fiber bundle lengths (FBLs) in tracts known to innervate frontal brain regions, including the anterior corpus callosum (AntCC), the cingulate gyrus segment of the cingulum bundle (CING), uncinate fasciculus (UNC), and the superior longitudinal fasciculus (SLF). Performance on the Go/NoGo task was measured by the number of commission errors standardized to reaction time. Hierarchical regression models revealed that shorter FBLs in the CING (p < 0.05) and the bilateral UNC (p < 0.01) were associated with lower inhibitory performance after adjusting for multiple comparisons, supporting a disconnection model of response inhibition in older adults. Prospective longitudinal studies are needed to examine the evolution of inhibitory errors in older adult populations and potential for therapeutic intervention.

Indexed as

Healthy AgingInhibition, PsychologicalNerve Fibers, MyelinatedWhite MatterAgedBrainCorpus CallosumDiffusion Tensor ImagingFemaleGyrus CinguliHumansMaleMiddle AgedNeural PathwaysNeuropsychological TestsReaction TimeAgingGo/NoGoInhibitionMRI fiber bundle lengthQuantitative diffusion tensor imagingWhite matter

Identifiers

PMID31209835
PMCPMC6906229
OpenAlexW2953197644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.