Evidence map›Paper›PMID 31209780›Full record

ArticleMolecular imaging and biology2020

Validation of Parametric Methods for [

Nathalie Mertens, Ralph Paul Maguire, Kim Serdons, Brigitte Lacroix, Joel Mercier, David Sciberras, Koen Van Laere, Michel Koole

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 83 citations in OpenAlex.

  1. Trial
  2. Changes in synaptic density in the subacute phase after ischemic stroke: AJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  3. Motor signs in late life depression relate to altered subcortical synaptic density and gray matter volume: anNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Review
  5. Assessment of cerebral drug occupancy in humans using a single PET-scan: A [European journal of nuclear medicine and molecular imaging · 2024
    Observational
  6. Article
  7. Article
  8. SV2A PET imaging in human neurodegenerative diseases.Frontiers in aging neuroscience · 2024
    Review
  9. Article
  10. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  11. Article
  12. Imaging of Synaptic Density in Neurodegenerative Disorders.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  17. Kinetics and 28-day test-retest repeatability and reproducibility of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  18. Article
  19. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nathalie MertensDepartment of Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium. nathalie.mertens@kuleuven.be.ORCID 0000-0002-2409-7586
Ralph Paul MaguireUCB Pharma, Braine-l'Alleud, Belgium.
Kim SerdonsDepartment of Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium.
Brigitte LacroixUCB Pharma, Braine-l'Alleud, Belgium.
Joel MercierUCB Pharma, Braine-l'Alleud, Belgium.
David SciberrasUCB Pharma, Braine-l'Alleud, Belgium.
Koen Van LaereDepartment of Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium.
Michel KooleDepartment of Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium.
KU Leuven · BEUCB Pharma (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([ PROCEDURES: Ten healthy volunteers (8 M/2F; age 27.6 ± 10.0 years) underwent a 90-min dynamic [

resultsFor all methods, highly significant correlations were found between regional, parametric BP

conclusionSRTM2 is the preferred method for a voxelwise analysis of dynamic [

Indexed as

Carbon RadioisotopesAdolescentAdultFemaleHumansMagnetic Resonance ImagingMaleMultimodal ImagingPositron-Emission TomographyRadiopharmaceuticalsReference ValuesWhite MatterYoung AdultCarbon-11Carbon RadioisotopesRadiopharmaceuticals[11C]UCB-J PETParametric mapsReference tissueSubcortical white matterSynaptic density

Identifiers

PMID31209780
OpenAlexW2950389023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.