Evidence map›Paper›PMID 31209671›Full record

ArticleAnnals of surgical oncology2019

Assessment of the Value of Comorbidity Indices for Risk Adjustment in Colorectal Surgery Patients.

Paul Strombom, Maria Widmar, Metin Keskin, Renee L Gennarelli, Patricio Lynn, J Joshua Smith, Jose G Guillem, Philip B Paty, Garrett M Nash, Martin R Weiser and 1 more

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Predictive Ability of Comorbidity Indices for Surgical Morbidity and Mortality: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paul StrombomDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maria WidmarDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Metin KeskinDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Renee L GennarelliDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Patricio LynnDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
J Joshua SmithDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jose G GuillemDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Philip B PatyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Garrett M NashDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Martin R WeiserDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Julio Garcia-AguilarDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. garciaaj@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
National Cancer Institute P30 CA008748NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

background and purposeComorbidity indices (CIs) are widely used in retrospective studies. We investigated the value of commonly used CIs in risk adjustment for postoperative complications after colorectal surgery.

methodsPatients undergoing colectomy without stoma for colonic neoplasia at a single institution from 2009 to 2014 were included. Four CIs were calculated or obtained for each patient, using administrative data: Charlson-Deyo (CCI-D), Charlson-Romano (CCI-R), Elixhauser Comorbidity Score, and American Society of Anesthesiologists classification. Outcomes of interest in the 90-day postoperative period were any surgical complication, surgical site infection (SSI), Clavien-Dindo (CD) grade 3 or higher complication, anastomotic leak or abscess, and nonroutine discharge. Base models were created for each outcome based on significant bivariate associations. Logistic regression models were constructed for each outcome using base models alone, and each index as an additional covariate. Models were also compared using the DeLong and Clarke-Pearson method for receiver operating characteristic (ROC) curves, with the CCI-D as the reference.

resultsOverall, 1813 patients were included. Postoperative complications were reported in 756 (42%) patients. Only 9% of patients had a CD grade 3 or higher complication, and 22.8% of patients developed an SSI. Multivariable modeling showed equivalent performance of the base model and the base model augmented by the CIs for all outcomes. The ROC curves for the four indices were also similar.

conclusionsThe inclusion of CIs added little to the base models, and all CIs performed similarly well. Our study suggests that CIs do not adequately risk-adjust for complications after colorectal surgery.

Indexed as

AgedAnastomotic LeakColorectal NeoplasmsColorectal SurgeryComorbidityFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedNew YorkPostoperative ComplicationsPredictive Value of TestsRetrospective StudiesRisk Adjustment

Identifiers

PMID31209671
PMCPMC6684474

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.