ArticleNeuroradiology2019
Brain tissue and myelin volumetric analysis in multiple sclerosis at 3T MRI with various in-plane resolutions using synthetic MRI.
Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Synthetic MRI and radiomics in multiple sclerosis: improving precision in diagnosis and prognosis.Radiological physics and technology · 2026Review
- Two-Minute Deep Learning-Powered Brain Quantitative Mapping: Accelerating Clinical Imaging With Synthetic Magnetic Resonance Imaging.JMIR medical informatics · 2026Article
- A multinational study of deep learning-based image enhancement for multiparametric glioma MRI.Scientific reports · 2025Article
- Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes.NPJ Parkinson's disease · 2025Article
- Technical aspects and clinical applications of synthetic MRI: a scoping review.Diagnosis (Berlin, Germany) · 2025Article
- Quantitative MR Imaging of the Breast.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Evaluating T1, T2 Relaxation, and Proton Density in Normal Brain Using Synthetic MRI with Fast Imaging Protocol.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
- Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Predicting of Ki-67 Expression Level Using Diffusion-Weighted and Synthetic Magnetic Resonance Imaging in Invasive Ductal Breast Cancer.The breast journal · 2023Article
- Accelerated Synthetic MRI with Deep Learning-Based Reconstruction for Pediatric Neuroimaging.AJNR. American journal of neuroradiology · 2022Article
- The effect of scan parameters on T1, T2 relaxation times measured with multi-dynamic multi-echo sequence: a phantom study.Physical and engineering sciences in medicine · 2022Article
- Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics.Neuroradiology · 2022Article
- Clinical adaptation of synthetic MRI-based whole brain volume segmentation in children at 3 T: comparison with modified SPM segmentation methods.Neuroradiology · 2022Article
- Exploratory Radiomic Analysis of Conventional vs. Quantitative Brain MRI: Toward Automatic Diagnosis of Early Multiple Sclerosis.Frontiers in neuroscience · 2021Article
- Variability and Standardization of Quantitative Imaging: Monoparametric to Multiparametric Quantification, Radiomics, and Artificial Intelligence.Investigative radiology · 2020Review
- Article
- Clinical Feasibility of Automated Brain Tissue and Myelin Volumetry of Normal Brian Using Synthetic Magnetic Resonance Imaging With Fast Imaging Protocol: A Single-Center Pilot Study.Journal of computer assisted tomographyArticle
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeSynthetic MRI (SyMRI) enables automatic brain tissue and myelin volumetry based on the quantification of R1 and R2 relaxation rates and proton density. This study aimed to determine the validity of SyMRI brain tissue and myelin volumetry using various in-plane resolutions at 3T in patients with multiple sclerosis (MS).
methodsWe scanned 19 MS patients and 10 healthy age- and gender-matched controls using a 3T MR scanner with in-plane resolutions of 0.8, 1.8, and 3.6 mm. The acquisition times were 5 min 8 s, 2 min 52 s, and 2 min 1 s, respectively. White matter (WM), gray matter (GM), cerebrospinal fluid (CSF), and myelin and non-WM/GM/CSF (NoN) volumes; brain parenchymal volume (BPV); and intracranial volume (ICV) were compared between different in-plane resolutions. These parameters were also compared between both groups, after ICV normalization.
resultsNo significant differences in measured volumes were noted between the 0.8 and 1.8 mm in-plane resolutions, except in NoN and CSF for healthy controls and NoN for MS patients. Meanwhile, significant volumetric differences were noted in most brain tissues when compared between the 3.6 and 0.8 or 1.8 mm resolution for both healthy controls and MS patients. The normalized WM volume, myelin volume, and BPV showed significant differences between controls and MS patients at in-plane resolutions of 0.8 and 1.8 mm.
conclusionsSyMRI brain tissue and myelin volumetry with in-plane resolution as low as 1.8 mm can be useful in the evaluation of MS with a short acquisition time of < 3 min.
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